Regulation of mast cell activation by complement-derived peptides

It is known for more than 25 years that the complement-derived anaphylatoxic peptides, C3a, C4a and C5a are potent activators of basophils and certain types of mast cells. Although tissue distribution of receptors for C3a and C5a well exceeds myeloid cells, apparently they are not expressed on mucos...

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Bibliographic Details
Published in:Immunology Letters 2004-03, Vol.92 (1), p.39-42
Main Authors: Erdei, Anna, Andrásfalvy, Márton, Péterfy, Hajna, Tóth, Gábor, Pecht, Israel
Format: Article
Language:English
Subjects:
Activation
Anaphylatoxic peptides
Animals
C3a
C5a
Complement C3a - immunology
Complement C3a - physiology
Complement System Proteins - immunology
Complement System Proteins - physiology
Humans
Inhibition
Mast Cells - immunology
Mast Cells - physiology
Peptide Fragments - immunology
Peptide Fragments - physiology
Serosal and mucosal type mast cells
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Summary:It is known for more than 25 years that the complement-derived anaphylatoxic peptides, C3a, C4a and C5a are potent activators of basophils and certain types of mast cells. Although tissue distribution of receptors for C3a and C5a well exceeds myeloid cells, apparently they are not expressed on mucosal type mast cells, consequently these cells are not activated by C3a and C5a. Our results do however demonstrate that C3a and peptides related to this complement activation product are able to inhibit FcεRI-clustering induced activation of mucosal type mast cells—such as RBL-2H3 cells and bone-marrow derived mast cells. Based on the current results we propose the presence of separate “activator” and “inhibitor” sequence motifs in C3a which are in balance under physiologic conditions.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2003.11.019