Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy

Objectives: To study the possible interaction between ascorbic acid (AA) and oestradiol (E2) in postmenopausal women on hormone replacement therapy (HRT). Methods: We studied 25 healthy postmenopausal women who had used percutaneous E2 gel at same dose for 10–12 months, at which time the plasma E2 c...

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Bibliographic Details
Published in:Maturitas 2002-06, Vol.42 (2), p.129-135
Main Authors: Vihtamäki, Tarja, Parantainen, Jouko, Koivisto, Anna-Maija, Metsä-Ketelä, Timo, Tuimala, Risto
Format: Article
Language:English
Subjects:
Antioxidant
Ascorbic acid
Ascorbic Acid - administration & dosage
Ascorbic Acid - therapeutic use
Biological and medical sciences
Estradiol - blood
Estrogen Replacement Therapy
Female
Hormone replacement therapy
Hormones. Endocrine system
Humans
Medical sciences
Middle Aged
Oestradiol
Pharmacology. Drug treatments
Postmenopause
Time Factors
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Summary:Objectives: To study the possible interaction between ascorbic acid (AA) and oestradiol (E2) in postmenopausal women on hormone replacement therapy (HRT). Methods: We studied 25 healthy postmenopausal women who had used percutaneous E2 gel at same dose for 10–12 months, at which time the plasma E2 concentrations were stabilized. The subjects were treated with 1000 mg of AA daily for 3 months and blood samples for assay of AA and E2 were taken at 0, 1 and 3 months. Results: After 1 month of AA treatment, there was an overall increase of 20.8% in E2 levels in the group as a whole. Greater responses were seen in two subgroups. In women with initially the lowest plasma concentrations of AA (
ISSN:0378-5122
1873-4111
DOI:10.1016/S0378-5122(02)00005-1