3-Deoxy-3-[18F]fluorothymidine-positron emission tomography for noninvasive assessment of proliferation in pulmonary nodules

We investigated whether uptake of the thymidine analogue 3-deoxy-3-[(18)F]fluorothymidine ([(18)F]FLT) reflects proliferation in solitary pulmonary nodules (SPNs). Thirty patients with SPNs were prospectively examined with positron emission tomography. Standardized uptake values were calculated for...

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Published in:Cancer research (Chicago, Ill.) Ill.), 2002-06, Vol.62 (12), p.3331-3334
Main Authors: BUCK, Andreas K, SCHIRRMEISTER, Holger, HETZEL, Martin, VON DER HEIDE, Mareike, HALTER, Gisela, GLATTING, Gerhard, MATTFELDT, Torsten, LIEWALD, Florian, RESKE, Sven N, NEUMAIER, Bernd
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cell Division - physiology
Dideoxynucleosides - pharmacokinetics
Female
Fluorine Radioisotopes
Humans
Immunohistochemistry
Ki-67 Antigen - metabolism
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Male
Medical sciences
Middle Aged
Pneumology
Prospective Studies
Radiopharmaceuticals - pharmacokinetics
Tomography, Emission-Computed - methods
Tumors of the respiratory system and mediastinum
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Summary:We investigated whether uptake of the thymidine analogue 3-deoxy-3-[(18)F]fluorothymidine ([(18)F]FLT) reflects proliferation in solitary pulmonary nodules (SPNs). Thirty patients with SPNs were prospectively examined with positron emission tomography. Standardized uptake values were calculated for quantification of FLT uptake. Histopathology revealed 22 malignant and 8 benign lesions. Proliferation was evaluated by Ki-67 immunostaining and showed a mean proliferation fraction of 30.9% (range, 1-65%) in malignant SPNs and
ISSN:0008-5472