Chronic Evaluation of the Cleveland Clinic CorAide Left Ventricular Assist System in Calves

• Published in: Artificial organs 2002-06, Vol.26 (6), p.529-533
• Main Authors: Fukamachi, Kiyotaka, Ochiai, Yoshie, Doi, Kazuyoshi, Massiello, Alex L., Medvedev, Alexander L., Horvath, David J., Gerhart, Renee L., Chen, Ji-Feng, Krogulecki, Alexandra Y., Takagaki, Masami, Howard, Michael W., Kopcak Jr, Michael W., Golding, Leonard A.R.
• Format: Article
• Language: English
• Subjects: Animals; Anticoagulation; Cattle; Centrifugal pump; Disease Models, Animal; Evaluation Studies as Topic; Heart-Assist Devices; Hemodynamics - physiology; Hemolysis; Left ventricular assist device; Prosthesis Design; Reproducibility of Results; Time Factors; Ventricular Dysfunction, Left - physiopathology; Ventricular Dysfunction, Left - therapy
• ISSN: 0160-564X; 1525-1594
• DOI: 10.1046/j.1525-1594.2002.06994.x

: The Cleveland Clinic CorAide left ventricular assist system is based on a third‐generation, implantable, centrifugal pump in which a rotating assembly is suspended fully. To evaluate chronic in vivo system performance and biocompatibility, the CorAide blood pump was implanted in 18 calves for either 1 month or 3 months. Hemodynamics were stable in all calves with a mean pump flow of 5.9 ± 1.2 L/min and a mean systemic arterial pressure of 98 ± 5 mm Hg. There were no incidences of bleeding, organ dysfunction, or mechanical failure in any of the 18 calves. Hemolysis occurred in only 1 calf due to outflow graft stenosis. Thrombus inside the pump, seen in 4 of the first 6 cases, was totally eliminated by a final redesign in the remaining cases, including the last 6 implants conducted without anticoagulation therapy. The CorAide blood pump demonstrated good biocompatibility and reliable, effective system performance.