Acute exposure to CXC chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices

Brain levels of CXC chemokine ligand 10 (CXCL10) are elevated in a number of neuropathological conditions. To determine its impact on neuronal function, we measured synaptic transmission and plasticity in hippocampal slices prepared from transgenic (TG) mice with chronic astroglial production of CXC...

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Bibliographic Details
Published in:Journal of neuroimmunology 2004-05, Vol.150 (1), p.37-47
Main Authors: Vlkolinský, Roman, Siggins, George R., Campbell, Iain L., Krucker, Thomas
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
Astrocytes - immunology
Astrocytes - metabolism
Astrocytes - physiology
Chemokine CXCL10
Chemokines, CXC - biosynthesis
Chemokines, CXC - genetics
Chemokines, CXC - pharmacology
Chemokines, CXC - physiology
CXCR3
Excitatory Postsynaptic Potentials - genetics
Excitatory Postsynaptic Potentials - immunology
In Vitro Techniques
IP-10
Long-Term Potentiation - genetics
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Neural Inhibition - genetics
Neural Inhibition - immunology
NeuroAIDS
Neurodegeneration
Neuronal Plasticity - genetics
Neuronal Plasticity - immunology
Paired-pulse facilitation
Receptors, Chemokine - deficiency
Receptors, Chemokine - genetics
Receptors, Chemokine - physiology
Receptors, CXCR3
Recombinant Proteins - pharmacology
Synapses - genetics
Synapses - immunology
Time Factors
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Description
Summary:Brain levels of CXC chemokine ligand 10 (CXCL10) are elevated in a number of neuropathological conditions. To determine its impact on neuronal function, we measured synaptic transmission and plasticity in hippocampal slices prepared from transgenic (TG) mice with chronic astroglial production of CXCL10. We also tested the acute effect of recombinant CXCL10 applied to slices from normal C57Bl/6J mice, CXCL10 TG mice and CXCR3 knock out (KO) mice. Chronic production of CXCL10 did not alter synaptic plasticity. By contrast, exogenous CXCL10 (10 ng/ml) significantly inhibited long-term potentiation (LTP) in slices from normal C57Bl/6J mice and CXCL10 TG. The effect was probably receptor-mediated because CXCL10-induced inhibition of LTP was not observed in CXCR3 KO mice. Our findings suggest that acute exposure to CXCL10 alters synaptic plasticity via CXCR3 in mouse hippocampus.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2004.01.011