Antimitochondrial activity displayed by the antimicrobial peptide microcin J25

In this report we studied the effect of the antimicrobial peptide, microcin J25, on the rat heart mitochondria. This peptide induced an important inhibition of the ATP synthesis with the concomitant enhancement of the ATP degradation. These effects were the result of two processes: on one hand, micr...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2004-05, Vol.317 (3), p.882-886
Main Authors: Niklison Chirou, Marı́a V., Minahk, Carlos J., Morero, Roberto D.
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Animals
Anti-Bacterial Agents - pharmacology
Bacteriocins - pharmacology
Membrane Fluidity - drug effects
Mitochondria, Heart - drug effects
Mitochondria, Heart - metabolism
Peptides
Rats
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Summary:In this report we studied the effect of the antimicrobial peptide, microcin J25, on the rat heart mitochondria. This peptide induced an important inhibition of the ATP synthesis with the concomitant enhancement of the ATP degradation. These effects were the result of two processes: on one hand, microcin J25 was able to insert into the membrane and hence alter its permeability with the consequent dissipation of the proton motive force. On the other, microcin J25 inhibited the enzymatic activity of the cytochrome c reductase (complex III) of the respiratory chain. The relevance of this study to the potential use of microcin J25 as an anti-tumoral agent is discussed.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2004.03.127