Antimitochondrial activity displayed by the antimicrobial peptide microcin J25

In this report we studied the effect of the antimicrobial peptide, microcin J25, on the rat heart mitochondria. This peptide induced an important inhibition of the ATP synthesis with the concomitant enhancement of the ATP degradation. These effects were the result of two processes: on one hand, micr...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical and biophysical research communications 2004-05, Vol.317 (3), p.882-886
Main Authors: Niklison Chirou, Marı́a V., Minahk, Carlos J., Morero, Roberto D.
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Animals
Anti-Bacterial Agents - pharmacology
Bacteriocins - pharmacology
Membrane Fluidity - drug effects
Mitochondria, Heart - drug effects
Mitochondria, Heart - metabolism
Peptides
Rats
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c449t-800291c50e7f89a903ecb60462fed4eacfa347c798212aea2ec743e002345ef53
cites cdi_FETCH-LOGICAL-c449t-800291c50e7f89a903ecb60462fed4eacfa347c798212aea2ec743e002345ef53
container_end_page 886
container_issue 3
container_start_page 882
container_title Biochemical and biophysical research communications
container_volume 317
creator Niklison Chirou, Marı́a V.
Minahk, Carlos J.
Morero, Roberto D.
description In this report we studied the effect of the antimicrobial peptide, microcin J25, on the rat heart mitochondria. This peptide induced an important inhibition of the ATP synthesis with the concomitant enhancement of the ATP degradation. These effects were the result of two processes: on one hand, microcin J25 was able to insert into the membrane and hence alter its permeability with the consequent dissipation of the proton motive force. On the other, microcin J25 inhibited the enzymatic activity of the cytochrome c reductase (complex III) of the respiratory chain. The relevance of this study to the potential use of microcin J25 as an anti-tumoral agent is discussed.
doi_str_mv 10.1016/j.bbrc.2004.03.127
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71825883</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006291X04006278</els_id><sourcerecordid>71825883</sourcerecordid><originalsourceid>FETCH-LOGICAL-c449t-800291c50e7f89a903ecb60462fed4eacfa347c798212aea2ec743e002345ef53</originalsourceid><addsrcrecordid>eNqFkMtKAzEUhoMoWi8v4EJm5W7Gk8tcAm5K8UrRjYK7kMmcwZTpzJikhb69qS2409WBw_f_nPMRckkho0CLm0VW185kDEBkwDPKygMyoSAhZRTEIZkAQJEyST9OyKn3CwBKRSGPyQnNoaKCsQl5mfbBLm0YzOfQN87qLtEm2LUNm6Sxfuz0Bpuk3iThExP9wxo31FtuxDHYBpOfjbF98szyc3LU6s7jxX6ekff7u7fZYzp_fXiaTeepEUKGtAKIZ5kcsGwrqSVwNHUBomAtNgK1aTUXpSllxSjTqBmaUnCMKS5ybHN-Rq53vaMbvlbog1pab7DrdI_DyquSViyvKv4vSOMpVHIZQbYD4zPeO2zV6OxSu42ioLa61UJtdautbgVcRd0xdLVvX9VLbH4je78RuN0BGGWsLTrljcXeYGMdmqCawf7V_w1H6pDs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18001939</pqid></control><display><type>article</type><title>Antimitochondrial activity displayed by the antimicrobial peptide microcin J25</title><source>Elsevier</source><creator>Niklison Chirou, Marı́a V. ; Minahk, Carlos J. ; Morero, Roberto D.</creator><creatorcontrib>Niklison Chirou, Marı́a V. ; Minahk, Carlos J. ; Morero, Roberto D.</creatorcontrib><description>In this report we studied the effect of the antimicrobial peptide, microcin J25, on the rat heart mitochondria. This peptide induced an important inhibition of the ATP synthesis with the concomitant enhancement of the ATP degradation. These effects were the result of two processes: on one hand, microcin J25 was able to insert into the membrane and hence alter its permeability with the consequent dissipation of the proton motive force. On the other, microcin J25 inhibited the enzymatic activity of the cytochrome c reductase (complex III) of the respiratory chain. The relevance of this study to the potential use of microcin J25 as an anti-tumoral agent is discussed.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2004.03.127</identifier><identifier>PMID: 15081422</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adenosine Triphosphate - metabolism ; Animals ; Anti-Bacterial Agents - pharmacology ; Bacteriocins - pharmacology ; Membrane Fluidity - drug effects ; Mitochondria, Heart - drug effects ; Mitochondria, Heart - metabolism ; Peptides ; Rats</subject><ispartof>Biochemical and biophysical research communications, 2004-05, Vol.317 (3), p.882-886</ispartof><rights>2004 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-800291c50e7f89a903ecb60462fed4eacfa347c798212aea2ec743e002345ef53</citedby><cites>FETCH-LOGICAL-c449t-800291c50e7f89a903ecb60462fed4eacfa347c798212aea2ec743e002345ef53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15081422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Niklison Chirou, Marı́a V.</creatorcontrib><creatorcontrib>Minahk, Carlos J.</creatorcontrib><creatorcontrib>Morero, Roberto D.</creatorcontrib><title>Antimitochondrial activity displayed by the antimicrobial peptide microcin J25</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>In this report we studied the effect of the antimicrobial peptide, microcin J25, on the rat heart mitochondria. This peptide induced an important inhibition of the ATP synthesis with the concomitant enhancement of the ATP degradation. These effects were the result of two processes: on one hand, microcin J25 was able to insert into the membrane and hence alter its permeability with the consequent dissipation of the proton motive force. On the other, microcin J25 inhibited the enzymatic activity of the cytochrome c reductase (complex III) of the respiratory chain. The relevance of this study to the potential use of microcin J25 as an anti-tumoral agent is discussed.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacteriocins - pharmacology</subject><subject>Membrane Fluidity - drug effects</subject><subject>Mitochondria, Heart - drug effects</subject><subject>Mitochondria, Heart - metabolism</subject><subject>Peptides</subject><subject>Rats</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqFkMtKAzEUhoMoWi8v4EJm5W7Gk8tcAm5K8UrRjYK7kMmcwZTpzJikhb69qS2409WBw_f_nPMRckkho0CLm0VW185kDEBkwDPKygMyoSAhZRTEIZkAQJEyST9OyKn3CwBKRSGPyQnNoaKCsQl5mfbBLm0YzOfQN87qLtEm2LUNm6Sxfuz0Bpuk3iThExP9wxo31FtuxDHYBpOfjbF98szyc3LU6s7jxX6ekff7u7fZYzp_fXiaTeepEUKGtAKIZ5kcsGwrqSVwNHUBomAtNgK1aTUXpSllxSjTqBmaUnCMKS5ybHN-Rq53vaMbvlbog1pab7DrdI_DyquSViyvKv4vSOMpVHIZQbYD4zPeO2zV6OxSu42ioLa61UJtdautbgVcRd0xdLVvX9VLbH4je78RuN0BGGWsLTrljcXeYGMdmqCawf7V_w1H6pDs</recordid><startdate>20040507</startdate><enddate>20040507</enddate><creator>Niklison Chirou, Marı́a V.</creator><creator>Minahk, Carlos J.</creator><creator>Morero, Roberto D.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20040507</creationdate><title>Antimitochondrial activity displayed by the antimicrobial peptide microcin J25</title><author>Niklison Chirou, Marı́a V. ; Minahk, Carlos J. ; Morero, Roberto D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-800291c50e7f89a903ecb60462fed4eacfa347c798212aea2ec743e002345ef53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacteriocins - pharmacology</topic><topic>Membrane Fluidity - drug effects</topic><topic>Mitochondria, Heart - drug effects</topic><topic>Mitochondria, Heart - metabolism</topic><topic>Peptides</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Niklison Chirou, Marı́a V.</creatorcontrib><creatorcontrib>Minahk, Carlos J.</creatorcontrib><creatorcontrib>Morero, Roberto D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Niklison Chirou, Marı́a V.</au><au>Minahk, Carlos J.</au><au>Morero, Roberto D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimitochondrial activity displayed by the antimicrobial peptide microcin J25</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2004-05-07</date><risdate>2004</risdate><volume>317</volume><issue>3</issue><spage>882</spage><epage>886</epage><pages>882-886</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>In this report we studied the effect of the antimicrobial peptide, microcin J25, on the rat heart mitochondria. This peptide induced an important inhibition of the ATP synthesis with the concomitant enhancement of the ATP degradation. These effects were the result of two processes: on one hand, microcin J25 was able to insert into the membrane and hence alter its permeability with the consequent dissipation of the proton motive force. On the other, microcin J25 inhibited the enzymatic activity of the cytochrome c reductase (complex III) of the respiratory chain. The relevance of this study to the potential use of microcin J25 as an anti-tumoral agent is discussed.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15081422</pmid><doi>10.1016/j.bbrc.2004.03.127</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0006-291X
ispartof Biochemical and biophysical research communications, 2004-05, Vol.317 (3), p.882-886
issn 0006-291X
1090-2104
language eng
recordid cdi_proquest_miscellaneous_71825883
source Elsevier
subjects Adenosine Triphosphate - metabolism
Animals
Anti-Bacterial Agents - pharmacology
Bacteriocins - pharmacology
Membrane Fluidity - drug effects
Mitochondria, Heart - drug effects
Mitochondria, Heart - metabolism
Peptides
Rats
title Antimitochondrial activity displayed by the antimicrobial peptide microcin J25
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T11%3A43%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antimitochondrial%20activity%20displayed%20by%20the%20antimicrobial%20peptide%20microcin%20J25&rft.jtitle=Biochemical%20and%20biophysical%20research%20communications&rft.au=Niklison%20Chirou,%20Mar%C4%B1%CC%81a%20V.&rft.date=2004-05-07&rft.volume=317&rft.issue=3&rft.spage=882&rft.epage=886&rft.pages=882-886&rft.issn=0006-291X&rft.eissn=1090-2104&rft_id=info:doi/10.1016/j.bbrc.2004.03.127&rft_dat=%3Cproquest_cross%3E71825883%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c449t-800291c50e7f89a903ecb60462fed4eacfa347c798212aea2ec743e002345ef53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=18001939&rft_id=info:pmid/15081422&rfr_iscdi=true