The absence of factor V Leiden mutation in Malays with recurrent spontaneous abortions

ABSTRACT Objectives The objectives of this study were to investigate the prevalence of factor V Leiden mutation in Malay women with recurrent spontaneous abortion and to clarify the contribution of the factor V Leiden mutation to recurrent miscarriages in these women. Design A prospective case contr...

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Published in:Australian & New Zealand journal of obstetrics & gynaecology 2002-05, Vol.42 (2), p.164-166
Main Authors: Yusoff, Narazah Mohd, Abdullah, Wan Zaidah, Ghazali, Selamah, Othman, Mohd Shukri, Baba, Abdul Aziz, Abdullah, Norazmi, Isa, Mohd Nizam, Chong, Chan Li
Format: Article
Language:English
Subjects:
Abortion, Habitual - epidemiology
Abortion, Habitual - genetics
Adolescent
Adult
Alleles
Base Sequence
Case-Control Studies
Factor V - genetics
Female
Genetic Predisposition to Disease
Humans
Incidence
Malaysia - epidemiology
Molecular Sequence Data
Point Mutation
Polymerase Chain Reaction
Pregnancy
Pregnancy Trimester, First
Pregnancy Trimester, Second
Prospective Studies
Recurrence
Reference Values
Risk Factors
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Summary:ABSTRACT Objectives The objectives of this study were to investigate the prevalence of factor V Leiden mutation in Malay women with recurrent spontaneous abortion and to clarify the contribution of the factor V Leiden mutation to recurrent miscarriages in these women. Design A prospective case control study between June 1999 and April 2000. Setting Hospital University Science of Malaysia, Kubang Kerian, Kelantan, and Maternal and Child Health Clinic, Pasir Mas, Kelantan, Malaysia. Samples A total of 46 Malay women with a history of three or more first or second trimester miscarriages were studied. The control group consisted of 46 parous women without obstetric complications. Methods Diagnosis of factor V Leiden mutation was made by examination of factor V Leiden allele product following Mnl I digestion of factor V Leiden alleles amplified by polymerase chain reaction. Results None of the 46 women with recurrent spontaneous abortion carried the mutation. Also, we found no subject carrying the factor V Leiden alleles in the control group. Conclusion These results suggest that that there is no association between the factor V Leiden mutation and recurrent spontaneous abortion in the Malay population.
ISSN:0004-8666
1479-828X
DOI:10.1111/j.0004-8666.2002.00164.x