Antioxidant enzyme activities are decreased in preterm infants and in neonates born via caesarean section

Objectives: To investigate the antioxidant defense potential of human neonates according to gestational age and mode of delivery. Study design: Four study groups were established, full-term normal spontaneous vaginal delivery (FT-NSVD, n=24), full-term caesarean section (FT-CS, n=19), preterm normal...

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Published in:European journal of obstetrics & gynecology and reproductive biology 2002-07, Vol.103 (2), p.136-139
Main Authors: Georgeson, George D, Szőny, Barnabás J, Streitman, Károly, Varga, Ilona Sz, Kovács, Attila, Kovács, László, László, Aranka
Format: Article
Language:English
Subjects:
Antioxidant enzymes
Antioxidants - metabolism
Biological and medical sciences
Caesarean section
Catalase - blood
Cesarean Section
Delivery, Obstetric
Delivery. Postpartum. Lactation
Disorders
Enzymes - blood
Female
Full-term neonate
Glutathione Peroxidase - blood
Gynecology. Andrology. Obstetrics
Humans
Infant, Newborn - metabolism
Infant, Premature - metabolism
Medical sciences
Neonate
Pregnancy
Preterm newborn
Reference Values
Superoxide Dismutase - blood
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Summary:Objectives: To investigate the antioxidant defense potential of human neonates according to gestational age and mode of delivery. Study design: Four study groups were established, full-term normal spontaneous vaginal delivery (FT-NSVD, n=24), full-term caesarean section (FT-CS, n=19), preterm normal spontaneous vaginal delivery (PT-NSVD, n=15) preterm caesarean section (PT-CS, n=21). The activity of catalase (CAT), glutathion peroxidase (GPX), Cu/Zn superoxide dismutase (Cu/Zn-SOD) were determined from cord blood. Statistical analysis was made by ANOVA. Results: CAT activity was significantly higher in full-term than in preterm newborns. In both the categories, neonates born via caesarean section had significantly lower CAT activities. GPX activity was significantly higher in the FT-NSVD group than in any other group. Cu/Zn-SOD activity was significantly higher in full-term neonates than in preterms and no difference was found related to the mode of delivery. Conclusions: Prematurity and caesarean section may cause a deficiency of antioxidant defense in human newborn.
ISSN:0301-2115
1872-7654
DOI:10.1016/S0301-2115(02)00050-7