Effects of four anaesthetic protocols on the neurological and cardiorespiratory variables of puppies born by caesarean section

Twenty-four bitches which had been in labour for less than 12 hours were randomly divided into four groups of six. They all received 0.5 mg/kg of chlorpromazine intravenously as premedication, followed 15 minutes later by either 8 mg/kg of thiopentone intravenously (group 1), 2 mg/kg of ketamine and...

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Bibliographic Details
Published in:Veterinary record 2004-03, Vol.154 (13), p.387-389
Main Authors: Luna, S. P. L., Cassu, R. N., Castro, G. B., Teixeira Neto, F. J., Silva, J. R., Lopes, M. D.
Format: Article
Language:English
Subjects:
anesthesia
Anesthesia, Inhalation - veterinary
Anesthesia, Intravenous - veterinary
Anesthetics, Combined - pharmacology
Animals
Bupivacaine - pharmacology
cesarean section
Cesarean Section - veterinary
Chlorpromazine - pharmacology
dogs
Dogs - physiology
Dogs - surgery
Enflurane - pharmacology
Epinephrine - pharmacology
Female
Heart Rate - drug effects
Ketamine - pharmacology
Lidocaine - pharmacology
Midazolam - pharmacology
Pregnancy
Propofol - pharmacology
puppies
Random Allocation
Reflex - drug effects
Respiration - drug effects
Thiopental - pharmacology
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Summary:Twenty-four bitches which had been in labour for less than 12 hours were randomly divided into four groups of six. They all received 0.5 mg/kg of chlorpromazine intravenously as premedication, followed 15 minutes later by either 8 mg/kg of thiopentone intravenously (group 1), 2 mg/kg of ketamine and 0.5 mg/kg of midazolam intravenously (group 2), 5 mg/kg of propofol intravenously (group 3), or 2.5 mg/kg of 2 per cent lidocaine with adrenaline and 0.625 mg/kg of 0.5 per cent bupivacaine with adrenaline epidurally (group 4). Except for group 4, the bitches were intubated and anaesthesia was maintained with enflurane. The puppies' heart and respiratory rates and their pain, sucking, anogenital, magnum and flexion reflexes were measured as they were removed from the uterus. The puppies' respiratory rate was higher after epidural anaesthesia. In general the puppies' neurological reflexes were most depressed after midazolam/ketamine, followed by thiopentone, propofol and epidural anaesthesia.
ISSN:0042-4900
2042-7670
DOI:10.1136/vr.154.13.387