Fibroblast growth factor 1 is produced prior to apolipoprotein E in the astrocytes after cryo-injury of mouse brain

We recently reported that fibroblast growth factor 1 (FGF-1) upregulates apolipoprotein E (apoE) synthesis and its secretion as high density lipoprotein (HDL) in cultured astrocytes potentially by an autocrine or paracrine mechanism [Biochim. Biopys. Acta 1589 (2002) 261]. In order to examine pathop...

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Bibliographic Details
Published in:Neurochemistry international 2004-07, Vol.45 (1), p.23-30
Main Authors: Tada, Toyohiro, Ito, Jin-ichi, Asai, Michiyo, Yokoyama, Shinji
Format: Article
Language:English
Subjects:
Acidic FGF
Animals
ApoE
Apolipoproteins E - analysis
Apolipoproteins E - biosynthesis
Apolipoproteins E - deficiency
Astrocytes
Astrocytes - chemistry
Astrocytes - metabolism
Astrocytes - pathology
Biological and medical sciences
Brain Injuries - metabolism
Brain Injuries - pathology
Brain Injuries - physiopathology
Brain injury
FGF-1
Fibroblast Growth Factor 1 - analysis
Fibroblast Growth Factor 1 - biosynthesis
Freezing
Fundamental and applied biological sciences. Psychology
HDL
Mice
Mice, Inbred C57BL
Mice, Knockout
Nitrogen - pharmacology
Vertebrates: nervous system and sense organs
Wound Healing - physiology
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Summary:We recently reported that fibroblast growth factor 1 (FGF-1) upregulates apolipoprotein E (apoE) synthesis and its secretion as high density lipoprotein (HDL) in cultured astrocytes potentially by an autocrine or paracrine mechanism [Biochim. Biopys. Acta 1589 (2002) 261]. In order to examine pathophysiological relevance of this reaction, we studied association of the production of FGF-1 and apoE in the post-injury mouse brain. After the spot-injury of the brain by liquid nitrogen, the surface size of the wound shrunk more rapidly in the C57BL/6 wild-type mice than the apoE-knock out C57BL/6 mice. Immunohistochemical analysis of the lesions revealed that production of FGF-1 was identified in the reactive astrocytes by the day 2 after the injury in both types of mouse, prior to the production of apoE confirmed by the day 4 in the wild-type. These findings were consistent with our in-vitro observations and hypothesis that FGF-1 upregulates apoE synthesis and subsequently HDL production in the reactive astrocytes by an autocrine or paracrine manner. FGF-1 thus would exert its effect after the CNS damage through apoE secretion.
ISSN:0197-0186
1872-9754
DOI:10.1016/j.neuint.2004.01.002