Numerical chromosomal aberrations in papillary renal cortical tumors: Relationship with histopathologic features

• Published in: Virchows Archiv : an international journal of pathology 2002-06, Vol.440 (6), p.604-609
• Main Authors: HENKE, R.-P, ERBERSDOBLER, A
• Format: Article
• Language: English
• Subjects: Adenoma - genetics; Adenoma - pathology; Biological and medical sciences; Carcinoma, Papillary - genetics; Carcinoma, Papillary - pathology; Chromosome Aberrations; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 20; Chromosomes, Human, Pair 7; Humans; Kidney Cortex - pathology; Kidney Neoplasms - classification; Kidney Neoplasms - genetics; Kidney Neoplasms - pathology; Kidneys; Medical sciences; Nephrology. Urinary tract diseases; Tumors of the urinary system
• ISSN: 0945-6317; 1432-2307
• DOI: 10.1007/s004280100519

Previous studies have indicated that a combined trisomy of chromosomes 7 and 17 is a constant finding in papillary renal cortical adenomas and that papillary renal cell carcinomas are marked by additional trisomies such as trisomy 12, 16, and 20. The aim of our study was to compare this cytogenetic classification of papillary renal cortical tumors with conventional histopathologic classification. We performed interphase cytogenetics with enumeration probes for chromosomes 7, 12, 16, 17, and 20 on 41 papillary tumors found in 21 nephrectomy and 10 autopsy kidneys. A total of 38 tumors harbored gains of chromosomes 7 or 17, and most of these showed a trisomic signal distribution. The three tumors with normal copy numbers for chromosomes 7 and 17 were a papillary grade-2 carcinoma, a small adenoma (both with distinctive oxyphilic cytoplasm), and a papillary carcinoma with focally clear cells. Gains for chromosomes 12, 16, or 20 were found in 21 tumors and were significantly associated with the presence of histologic criteria of malignancy ( P