Gene-gene interactions between glutathione-s transferase M1 and matrix metalloproteinase 9 in the formation of hereditary predisposition to chronic obstructive pulmonary disease

The incidence of allele variants of glutathione-S transferase M1 xenobiotic detoxification gene and matrix metalloproteinase 9 gene was analyzed in patients with chronic obstructive pulmonary disease. A strict gene-gene interaction between these two genes in the formation of hereditary predispositio...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2004-01, Vol.137 (1), p.64-66
Main Authors: Yanchina, E D, Ivchik, T V, Shvarts, E I, Kokosov, A N, Khodzhayantz, N E
Format: Article
Language:English
Subjects:
Case-Control Studies
Female
Gene Frequency
Genetic Predisposition to Disease - genetics
Genotype
Glutathione Transferase - genetics
Humans
Male
Matrix Metalloproteinase 9 - genetics
Pulmonary Disease, Chronic Obstructive - genetics
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Summary:The incidence of allele variants of glutathione-S transferase M1 xenobiotic detoxification gene and matrix metalloproteinase 9 gene was analyzed in patients with chronic obstructive pulmonary disease. A strict gene-gene interaction between these two genes in the formation of hereditary predisposition to this disease was first demonstrated. The combination of glutathione-S transferase M1 genotype 0/0 and matrix metalloproteinase 9 mutant allele (-15621) is a risk factor for chronic obstructive pulmonary disease (OR-7.7).
ISSN:0007-4888
1573-8221
DOI:10.1023/B:BEBM.0000024389.16247.0a