Development of Patient-Friendly Preparations: Preparation of a New Allopurinol Mouthwash Containing Polyethylene(oxide) and Carrageenan

• Published in: Drug development and industrial pharmacy 2004-01, Vol.30 (2), p.151-161
• Main Authors: Hanawa, Takehisa, Masuda, Nami, Mohri, Kiminori, Kawata, Keishi, Suzuki, Masahiko, Nakajima, Shin'ichiro
• Format: Article
• Language: English
• Subjects: Adhesiveness; Allopurinol; Allopurinol - administration & dosage; Allopurinol - chemistry; Biological and medical sciences; Carboxymethylcellulose Sodium - chemistry; Carrageenan - chemistry; Elasticity; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - chemistry; Gels; General pharmacology; Iota-carrageenan; Medical sciences; Mouth Mucosa; Mouthwash; Mouthwashes; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Polyethylene Glycols - chemistry; Polyethylene(oxide); Stomatitis; Viscosity
• ISSN: 0363-9045; 1520-5762
• DOI: 10.1081/DDC-120028710

Stomatitis is a harmful side effect induced by high and or multiple dosing of cytotoxic drugs such as 5-fluorouracil. Allopurinol mouthwash has been used to prevent stomatitis induced by cancer chemotherapy. In the present study, the pharmaceutical utility of allopurinol mouthwash (Alkox-mw), which consists of polyethylene(oxide) (Alkox®) and iota-carrageenan (INA), was investigated as a possible material for a new oral dosage preparation for improving the adhesiveness onto the oral mucosa. From the observation of the gel formation, which was studied as a function of the variety of the added Alkox® and or INA, the preferential compositions of Alkox®-mw (Alkox®:INA% ratio) seemed to be 1.0:(0-1.0) and (0-3.0):0.4, respectively. The adhesiveness and the spinnability of various allopurinol mouthwashes were also investigated using a creep meter. The adhesiveness of Alkox-mw increased with the increase in the amount of added Alkox®. Furthermore, the adhesion force of Alkox®-mw was greater than that of allopurinol mouthwash consisting of sodium carboxymethylcellulose (CMC-Na). From the in vitro assessment of mimicking the effusion of the allopurinol mouthwashes from the surface of the oral mucosa, the effusion of Alkox®-mws was retarded by the added Alkox. The results obtained in the present study suggest that Alkox®-mws may be useful as a new dosage form that adheres to the oral mucosa.