Intravesical Bacillus Calmette-Guerin Treatment Improves Patient Survival in T1G3 Bladder Tumours

• Published in: European urology 2002-06, Vol.41 (6), p.635-642
• Main Authors: Patard, Jean-Jacques, Rodriguez, Alejandro, Leray, Emmanuelle, Rioux-Leclercq, Nathalie, Guillé, François, Lobel, Bernard
• Format: Article
• Language: English
• Subjects: Adjuvants, Immunologic - administration & dosage; Administration, Intravesical; Adult; Aged; Aged, 80 and over; BCG vaccine; BCG Vaccine - administration & dosage; Bladder neoplasm; Carcinoma; Carcinoma, Transitional Cell - pathology; Carcinoma, Transitional Cell - therapy; Cohort Studies; Combined Modality Therapy; Cystectomy; Disease-Free Survival; Female; Follow-Up Studies; Humans; Immunotherapy; Longitudinal Studies; Male; Middle Aged; Neoplasm Staging; Prognosis; Proportional Hazards Models; Retrospective Studies; Survival; Transitional cell; Urinary Bladder Neoplasms - pathology; Urinary Bladder Neoplasms - therapy
• ISSN: 0302-2838; 1873-7560
• DOI: 10.1016/S0302-2838(02)00173-2

Objective: To study the clinical and pathological factors that affect recurrence, progression and survival in pT1G3 bladder tumours treated conservatively. Material and Methods: From January 1979 to December 1996, 80 patients were conservatively treated for pT1G3 bladder tumours. All patients were studied for potential prognostic factors such as: age, sex, previous tumour recurrence, tumour size, multiple tumours, carcinoma in situ, and intravesical instillations. A longitudinal, retrospective, observational and analytical study was conducted to evaluate four different types of events: recurrence, progression, overall survival, and disease-specific survival. The χ 2 (Fischer exact test) and student t tests were used to assess the prognostic value of the qualitative and quantitative variables. Estimations of the survival distributions were calculated according to the Kaplan-Meier method and compared with the Log rank test. Multivariate analysis of the data was performed with Cox proportional hazard models. Results: Among the 80 patients, 67 (84%) were men and 13 (16%) were women, with median age of 65.5 years. The median tumour size was 20 mm, most had single tumour (58.8%) and carcinoma in situ was found in six patients (7.5%). Thirty patients were treated with transurethral resection (TUR) of the bladder tumour and 50 patients were treated with TUR followed by BCG. The two groups of patients were comparable and followed up during a median time of 61 and 65 months, respectively ( p=0.454). Kaplan-Meier estimators and Log rank tests demonstrated that patients with TUR alone recurred ( p