Smoking is associated with reduced serum levels of the antioxidant enzyme, paraoxonase, in Type 2 diabetic patients

Aims  To analyse the association of smoking with paraoxonase (PON1) in Type 2 diabetic patients. Methods  Type 2 diabetic patients were recruited independently in two centres (Ancona, Italy and Geneva, Switzerland) and serum PON1 mass and activities were assayed. Current smoking status was establish...

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Bibliographic Details
Published in:Diabetic medicine 2004-05, Vol.21 (5), p.423-427
Main Authors: Boemi, M., Sirolla, C., Testa, R., Cenerelli, S., Fumelli, P., James, R. W.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aryldialkylphosphatase - blood
Biological and medical sciences
Coronary Disease - enzymology
Diabetes Mellitus, Type 2 - enzymology
Diabetes. Impaired glucose tolerance
Diabetic Angiopathies - enzymology
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
HDL
Humans
lipoproteins
Male
Medical sciences
Middle Aged
Oxidative Stress
Regression Analysis
risk factor
Risk Factors
Smoking - blood
Tobacco, tobacco smoking
Toxicology
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Summary:Aims  To analyse the association of smoking with paraoxonase (PON1) in Type 2 diabetic patients. Methods  Type 2 diabetic patients were recruited independently in two centres (Ancona, Italy and Geneva, Switzerland) and serum PON1 mass and activities were assayed. Current smoking status was established and its association with serum PON1 analysed. Results  Type 2 diabetic patients who smoked had significantly lower serum PON1 mass and activity. This was evident in both groups of patients, even though Swiss patients were composed of coronary patients. Multivariate analyses established that smoking was an independent determinant of serum PON1 status. Conclusions  Smoking is associated with reduced serum levels of the antioxidant enzyme, PON1, even against an already unfavourable background of diabetes and coronary disease. It suggests that a combination of smoking and diabetes may be particularly deleterious for PON1 and consequently for the anti‐oxidant capacity of high‐density lipoproteins.
ISSN:0742-3071
1464-5491
DOI:10.1111/j.1464-5491.2004.01163.x