Polymorphism in the Rhesus macaque (Macaca mulatta) NRAMP1 gene: lack of an allelic association to tuberculosis susceptibility

• Published in: Journal of medical primatology 2002-02, Vol.31 (1), p.8-16
• Main Authors: Deinard, Amos S., Lerche, Nicholas W., Smith, David Glenn
• Format: Article
• Language: English
• Subjects: Alleles; Animals; Base Sequence; Cation Transport Proteins - genetics; Genetic Predisposition to Disease; Macaca mulatta; Macaca mulatta - genetics; macaque; Molecular Sequence Data; Mycobacterium; Mycobacterium tuberculosis - pathogenicity; NRAMP1; Polymerase Chain Reaction; Polymorphism, Genetic; Sequence Analysis, DNA; Tuberculosis - genetics; Tuberculosis - veterinary; tuberculosis susceptibility
• ISSN: 0047-2565; 1600-0684
• DOI: 10.1034/j.1600-0684.2002.1o022.x

Although previous tuberculosis (TB) research has suggested that underlying genetic factors influence a host's response and ability to survive Mycobacterium infection, only recently has a gene been identified, the `natural resistance‐associated macrophage protein 1' (NRAMP1) gene, which provides a degree of natural resistance to infection by some Mycobacterium species. To date, however, the role that NRAMP1 may play in resistance to Mycobacterium infection has only been examined in mouse and man. Here, we present data generated at NRAMP1 among a group of rhesus macaques (Macaca mulatta) that were euthanized because of an outbreak of Mycobacterium tuberculosis during quarantine. Data were also generated on unrelated (and healthy) rhesus macaques in order to better determine the frequency and degree of genetic polymorphism within Macaca at the NRAMP1 locus. These data represent the first study designed to examine the role that NRAMP1 may play in TB susceptibility among rhesus macaques.