Cardiovascular protection by alcohol and polyphenols: role of nitric oxide

Cardiovascular disease, and in particular coronary heart disease (CHD), remains the leading cause of death in both men and women in the United States. Much epidemiologic evidence indicates that alcoholic beverages, and in particular red wine, results in a reduction in cardiovascular risk factors and...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2002-05, Vol.957 (1), p.115-121
Main Authors: Parks, Dale A, Booyse, Francois M
Format: Article
Language:English
Subjects:
Cardiovascular Diseases - prevention & control
Ethanol - pharmacology
Flavonoids
Humans
Models, Cardiovascular
Nitric Oxide - physiology
Phenols - pharmacology
Polymers - pharmacology
Polyphenols
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiovascular disease, and in particular coronary heart disease (CHD), remains the leading cause of death in both men and women in the United States. Much epidemiologic evidence indicates that alcoholic beverages, and in particular red wine, results in a reduction in cardiovascular risk factors and decreases mortality; however, the mechanisms of this cardiovascular protection remains elusive. This review discusses evidence to suggest that *NO plays a critical role in cardiovascular protection and that nitric oxide synthase (NOS) is the responsible cardioprotective protein (see Bolli et al. 1998. Basic Res. Cardiol. 93: 325-338).
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2002.tb02910.x