Selective microembolization of the circumflex coronary artery in an ovine model: dilated, ischemic cardiomyopathy and left ventricular dysfunction

Ventricular remodeling often occurs after myocardial infarction, yet the natural history remains unpredictable because of the chronicity of the process and therapeutic interventions involved. We induced cardiac dysfunction in an ovine model via selective microembolization of the circumflex coronary...

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Bibliographic Details
Published in:Journal of cardiac failure 2004-04, Vol.10 (2), p.174-183
Main Authors: Monreal, Gretel, Gerhardt, Mark A, Kambara, Atsushi, Abrishamchian, A.Reza, Bauer, John A, Goldstein, Andrew H
Format: Article
Language:English
Subjects:
Animals
Cardiomyopathy, Dilated - etiology
Cardiomyopathy, Dilated - physiopathology
Cardiomyopathy, Dilated - therapy
coronary microembolization
Coronary Vessels - physiopathology
Echocardiography
Embolization, Therapeutic
Heart failure
Hemodynamics - physiology
myocardial infarction
Sheep
Stroke Volume - physiology
Ventricular Dysfunction, Left - etiology
Ventricular Dysfunction, Left - physiopathology
Ventricular Dysfunction, Left - therapy
ventricular remodeling
Ventricular Remodeling - physiology
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Summary:Ventricular remodeling often occurs after myocardial infarction, yet the natural history remains unpredictable because of the chronicity of the process and therapeutic interventions involved. We induced cardiac dysfunction in an ovine model via selective microembolization of the circumflex coronary artery (LCx) to test the hypothesis that ventricular remodeling progresses following coronary microembolization for up to 24 months. Sheep underwent weekly selective microembolization of the LCx until left ventricular ejection fraction stabilized
ISSN:1071-9164
1532-8414
DOI:10.1016/j.cardfail.2003.08.013