Positional Cloning of an Obesity/Diabetes Susceptibility Gene(s) on Chromosome 11 in Pima Indians

: Prior results from our genomic scan in Pima Indians indicated an obesity locus in a region on chromosome 11q23‐24 that was also linked to diabetes. Bivariate linkage analysis for the combined phenotype “diabesity” gave the strongest evidence for linkage (LOD = 5.2). Our aim is to positionally clon...

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Published in:Annals of the New York Academy of Sciences 2002-06, Vol.967 (1), p.258-264
Main Authors: BAIER, LESLIE, KOVACS, PETER, WIEDRICH, CHRISTOPHER, CRAY, KIMBERLY, SCHEMIDT, AMY, SHEN, GONG-QING, SUTHERLAND, JEFFREY, THUILLEZ, PAMELA, MULLER, YUNHUA LI, TRAURIG, MICHAEL, BOGARDUS, CLIFTON
Format: Article
Language:English
Subjects:
Chromosome Mapping
Chromosomes, Human, Pair 11
Diabetes Mellitus, Type 2 - genetics
Humans
Indians, North American - genetics
Linkage Disequilibrium
linkage disequilibrium mapping
obesity
Obesity - genetics
Polymorphism, Single Nucleotide
single nucleotide polymorphisms
type 2 diabetes
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Summary:: Prior results from our genomic scan in Pima Indians indicated an obesity locus in a region on chromosome 11q23‐24 that was also linked to diabetes. Bivariate linkage analysis for the combined phenotype “diabesity” gave the strongest evidence for linkage (LOD = 5.2). Our aim is to positionally clone the gene(s) responsible for the linkage. Linkage disequilibrium mapping is being used to narrow the chromosomal region. Single nucleotide polymorphisms (SNPs) are being systematically identified and genotyped at 50‐kb intervals across the region of linkage. To date, 455 SNPs have been genotyped in 1229 Pimas. A region containing a cluster of SNPs strongly associated with BMI and a second region, approximately 2 Mb telomeric, containing a cluster of SNPs associated with diabetes have been preliminarily identified.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2002.tb04281.x