Mechanisms of Hepatoprotection by Nitric Oxide

: Nitric oxide (NO) exerts numerous antiapoptotic effects on hepatocytes in settings of inflammation and tissue damage. These actions of NO are modulated by a variety of mechanisms under both physiologic and pathologic conditions. Nitric oxide inhibits cell death or apoptosis by modulation of heat s...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2002-05, Vol.962 (1), p.415-422
Main Authors: WANG, YINNA, VODOVOTZ, YORAM, KIM, PETER K.M., ZAMORA, RUBEN, BILLIAR, TIMOTHY R.
Format: Article
Language:English
Subjects:
Animals
Apoptosis - physiology
Caspases - metabolism
Cytoprotection - physiology
Heat-Shock Proteins - metabolism
Hepatocytes - drug effects
Mitochondria - drug effects
Nitric Oxide - pharmacology
Signal Transduction - physiology
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Summary:: Nitric oxide (NO) exerts numerous antiapoptotic effects on hepatocytes in settings of inflammation and tissue damage. These actions of NO are modulated by a variety of mechanisms under both physiologic and pathologic conditions. Nitric oxide inhibits cell death or apoptosis by modulation of heat shock proteins, S‐nitrosylation of caspases at their catalytic site cysteine residue, triggering of the cGMP pathway, and prevention of mitochondrial dysfunction. Our preliminary studies also suggest that NO can modulate apoptosis‐related genes in a manner consistent with an antiapoptotic effect. This review focuses on these molecular mechanisms of cytoprotection by NO.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2002.tb04085.x