Reduced plasma homocysteine in obese red wine consumers: a potential contributor to reduced cardiovascular risk status

Moderate alcohol consumption is associated with improved vascular risk profile and decreased mortality in the middle aged. An elevated homocysteine concentration is an independent risk factor for cardiovascular disease. To examine the relationship between alcohol consumption and homocysteine concent...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical nutrition 2002-07, Vol.56 (7), p.608-614
Main Authors: DIXON, J. B, DIXON, M. E, O'BRIEN, P. E
Format: Article
Language:English
Subjects:
Adult
Alcohol
Alcohol Drinking - blood
Alcohol use
Alcoholic Beverages
Beer
Biological and medical sciences
Body mass index
Body size
Cardiology. Vascular system
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - etiology
Clinical nutrition
Consumers
Coronary heart disease
Drinking of alcoholic beverages
Fasting
Female
Folic acid
Folic Acid - blood
Health aspects
Health risk assessment
Health risks
Heart
Homocysteine
Homocysteine - blood
Humans
Male
Measurement
Medical sciences
Metabolic diseases
Middle Aged
Obesity
Obesity, Morbid - blood
Obesity, Morbid - surgery
Overweight persons
Patients
Red wines
Risk
Risk analysis
Risk assessment
Risk factors
Variance analysis
Vitamin B 12 - blood
Vitamin B12
Wine
Wines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Moderate alcohol consumption is associated with improved vascular risk profile and decreased mortality in the middle aged. An elevated homocysteine concentration is an independent risk factor for cardiovascular disease. To examine the relationship between alcohol consumption and homocysteine concentrations in severely obese patients (body mass index (BMI)>35). A careful alcohol history was obtained from 350 (male:female 1:5) consecutive patients as part of preoperative assessment for surgical treatment of obesity. Data were obtained concerning amount, frequency, timing and type of alcohol consumption. Fasting homocysteine, serum folate and vitamin B(12) concentrations were measured. Differences between groups were assessed using Student t-test, and ANOVA. Linear regression was used to assess factors influencing homocysteine concentration. There is a U-shaped relationship between alcohol consumption and homocysteine concentrations, with light to moderate consumption being associated with lower concentrations. Those consuming
ISSN:0954-3007
1476-5640
DOI:10.1038/sj.ejcn.1601365