Necrolytic acral erythema: response to combination therapy with interferon and ribavirin

Necrolytic acral erythema is a papulosquamous and sometimes vesiculobullous eruption bearing clinical and histologic similarity to other necrolytic erythemas such as necrolytic migratory erythema, pseudoglucagonoma, and nutritional deficiency syndromes. Necrolytic acral erythema is distinguished by...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2004-05, Vol.50 (5), p.121-124
Main Authors: Hivnor, Chad M, Yan, Albert C, Junkins-Hopkins, Jacqueline M, Honig, Paul J
Format: Article
Language:English
Subjects:
Acrodermatitis - drug therapy
Acrodermatitis - etiology
Acrodermatitis - pathology
Antiviral Agents - therapeutic use
Biological and medical sciences
Child
Dermatology
Drug Therapy, Combination
Erythema - drug therapy
Erythema - etiology
Erythema - pathology
Female
Hepatitis C, Chronic - complications
Humans
Interferon-alpha - therapeutic use
Medical sciences
Necrosis
Parenteral Nutrition
Recombinant Proteins
Ribavirin - therapeutic use
Skin - pathology
Skin involvement in other diseases. Miscellaneous. General aspects
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Summary:Necrolytic acral erythema is a papulosquamous and sometimes vesiculobullous eruption bearing clinical and histologic similarity to other necrolytic erythemas such as necrolytic migratory erythema, pseudoglucagonoma, and nutritional deficiency syndromes. Necrolytic acral erythema is distinguished by its association with hepatitis C infection and its predominantly acral distribution. We describe a pediatric patient with necrolytic acral erythema whose eruption resolved with hyperalimentation and combination interferon and ribavirin therapy, despite the persistence of detectable viral load and continued hepatic and renal insufficiency.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2003.09.017