Differential Inflammatory and Immunological Responses in Tissue Regeneration and Repair

: Repair and regeneration, contrasting resolutions to injury, evoke distinct inflammatory responses. Wound repair evokes a more robust peripheral leukocytosis and is accompanied by a larger inflammatory infiltrate into the wound site. Proliferation of thymocytes and splenocytes was enhanced followin...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2002-06, Vol.961 (1), p.368-371
Main Author: SICARD, RAYMOND E.
Format: Article
Language:English
Subjects:
Animals
Cell Division
Fibroblasts - metabolism
Immune System - physiology
Inflammation
inflammatory responses
Leukocytes - metabolism
Muscle, Skeletal - metabolism
Rats
Regeneration
Spleen - cytology
Thymus Gland - cytology
Time Factors
Tissue Engineering - methods
tissue regeneration
Wound Healing
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Summary:: Repair and regeneration, contrasting resolutions to injury, evoke distinct inflammatory responses. Wound repair evokes a more robust peripheral leukocytosis and is accompanied by a larger inflammatory infiltrate into the wound site. Proliferation of thymocytes and splenocytes was enhanced following injury; however, the ability to be stimulated by myoblasts in coculure is lost by splenocytes harvested from rats undergoing wound repair. These data reflect differences in inflammatory and immunological responses between repair and regeneration and suggest potentially important dialogues occur between injured tissues and inflammatory cells that direct the course of injury resolution.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2002.tb03126.x