Delivery systems for bone growth factors - the new players in skeletal regeneration

ABSTRACT Given the challenge of an increasing elderly population, the ability to repair and regenerate traumatised or lost tissue is a major clinical and socio‐economic need. Pivotal in this process will be the ability to deliver appropriate growth factors in the repair cascade in a temporal and tig...

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Bibliographic Details
Published in:Journal of pharmacy and pharmacology 2004-04, Vol.56 (4), p.415-427
Main Authors: Rose, Felicity R. A. J., Hou, Qingpu, Oreffo, Richard O. C.
Format: Article
Language:English
Subjects:
Bone and Bones - physiology
Bone Diseases - drug therapy
Bone Diseases - therapy
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins - administration & dosage
Bone Morphogenetic Proteins - therapeutic use
Bone Regeneration
Carrier Proteins - administration & dosage
Carrier Proteins - therapeutic use
Cytokines - administration & dosage
Cytokines - therapeutic use
Drug Carriers
Genetic Therapy
Humans
Tissue Engineering
Transforming Growth Factor beta - administration & dosage
Transforming Growth Factor beta - therapeutic use
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Summary:ABSTRACT Given the challenge of an increasing elderly population, the ability to repair and regenerate traumatised or lost tissue is a major clinical and socio‐economic need. Pivotal in this process will be the ability to deliver appropriate growth factors in the repair cascade in a temporal and tightly regulated sequence using appropriately designed matrices and release technologies within a tissue engineering strategy. This review outlines the current concepts and challenges in growth factor delivery for skeletal regeneration and the potential of novel delivery matrices and biotechnologies to influence the healthcare of an increasing ageing population.
ISSN:0022-3573
2042-7158
DOI:10.1211/0022357023312