Tension Precedes Commitment—Even for a Stem Cell

The differentiation potential of stem cells is influenced by cell density. An article in the April issue of Developmental Cell (McBeath et al., 2004) demonstrates that lineage commitment by mesenchymal stem cells is regulated by shape-induced changes in Rho GTPase activity and cytoskeletal tension.

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Bibliographic Details
Published in:Molecular Cell 2004-04, Vol.14 (2), p.148-150
Main Author: Settleman, Jeffrey
Format: Article
Language:English
Subjects:
Actins - metabolism
Adipocytes - cytology
Animals
Cell Count
Cell Differentiation
Cell Lineage
Cell Size
Cytoskeleton - metabolism
Enzyme Activation
Fibronectins - metabolism
Humans
Mesenchymal Stromal Cells - cytology
Mesoderm - cytology
Models, Biological
Osteoblasts - cytology
rho GTP-Binding Proteins - metabolism
Stress, Mechanical
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Description
Summary:The differentiation potential of stem cells is influenced by cell density. An article in the April issue of Developmental Cell (McBeath et al., 2004) demonstrates that lineage commitment by mesenchymal stem cells is regulated by shape-induced changes in Rho GTPase activity and cytoskeletal tension.
ISSN:1097-2765
1097-4164
DOI:10.1016/S1097-2765(04)00207-2