Light traffic: photo-crosslinking a novel transport system

The Tat protein transporter is found in the membranes of many bacteria and in plant chloroplasts. This highly unusual transport machine moves folded and often oligomeric substrate proteins across energy-conserving membranes. A recent paper reports the first use of a photo-crosslinking approach to di...

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Bibliographic Details
Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2004-02, Vol.29 (2), p.55-57
Main Authors: Palmer, Tracy, Sargent, Frank, Berks, Ben C.
Format: Article
Language:English
Subjects:
Amino Acid Motifs
Amino Acid Sequence
Amino Acid Substitution
Arginine - metabolism
Bacteria - cytology
Bacterial Proteins - metabolism
Biological Transport
Chloroplasts - metabolism
Consensus Sequence
Cross-Linking Reagents - metabolism
Escherichia coli Proteins - metabolism
Gene Products, tat - metabolism
Light
Lysine - metabolism
Membrane Transport Proteins - chemistry
Membrane Transport Proteins - genetics
Membrane Transport Proteins - metabolism
Models, Biological
Plant Proteins - metabolism
Protein Folding
Protein Sorting Signals
Protein Transport - genetics
Substrate Specificity
Thylakoids - metabolism
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Summary:The Tat protein transporter is found in the membranes of many bacteria and in plant chloroplasts. This highly unusual transport machine moves folded and often oligomeric substrate proteins across energy-conserving membranes. A recent paper reports the first use of a photo-crosslinking approach to dissect the early recognition events between the transporter and its substrate.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2003.12.001