Low concentration of nitrite and nitrate in the cerebrospinal fluid from schizophrenic patients: a pilot study

Some evidence suggests a dysfunctional nitric oxide (NO) system in the brain of schizophrenic subjects. We measured the concentrations of the stable metabolites of NO, nitrite, and nitrate in the cerebrospinal fluid (CSF) from schizophrenic and control patients with other neurological disorders and...

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Bibliographic Details
Published in:Schizophrenia research 2004-06, Vol.68 (2), p.357-361
Main Authors: Ramirez, Jesus, Garnica, Rodrigo, Boll, Marie-Catherine, Montes, Sergio, Rios, Camilo
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Brain - metabolism
CSF
Female
Headache - cerebrospinal fluid
Headache - diagnosis
Humans
Male
Medical sciences
Nervous System Diseases - cerebrospinal fluid
Nervous System Diseases - diagnosis
Nitrate
Nitrates - cerebrospinal fluid
Nitric Oxide - metabolism
Nitrite
Nitrites - cerebrospinal fluid
Pilot Projects
Proprioception - physiology
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - cerebrospinal fluid
Schizophrenia - diagnosis
Schizophrenia - metabolism
Spinal Puncture
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Summary:Some evidence suggests a dysfunctional nitric oxide (NO) system in the brain of schizophrenic subjects. We measured the concentrations of the stable metabolites of NO, nitrite, and nitrate in the cerebrospinal fluid (CSF) from schizophrenic and control patients with other neurological disorders and found lowered levels in the schizophrenic group as compared with the control group. This finding supports the hypothesis of a NO system reduction in the brain of schizophrenic subjects.
ISSN:0920-9964
1573-2509
DOI:10.1016/S0920-9964(03)00070-7