Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people

The effect of the synthetic peptide bioregulator Vilon on structural and facultative heterochromatin of cultured lymphocytes from old people has been studied. The data obtained indicate that Vilon (a) induces unrolling (deheterochromatinization) of total heterochromatin; (b) activates synthetic proc...

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Published in:Biogerontology (Dordrecht) 2004-01, Vol.5 (2), p.73-79
Main Authors: Lezhava, Teimuraz, Khavison, Vladimir, Monaselidze, Jamlet, Jokhadze, Tinatin, Dvalishvili, Nana, Bablishvili, Nino, Barbakadze, Shota
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aging
Aging - physiology
Bacteria
Calorimetry, Differential Scanning
Cells, Cultured
Dipeptides - pharmacology
Gene Expression Regulation
Heterochromatin - chemistry
Heterochromatin - drug effects
Heterochromatin - metabolism
Humans
Lymphocytes - cytology
Lymphocytes - metabolism
Nucleic Acid Conformation
Polymorphism, Genetic
Ribosomes - genetics
Ribosomes - metabolism
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Summary:The effect of the synthetic peptide bioregulator Vilon on structural and facultative heterochromatin of cultured lymphocytes from old people has been studied. The data obtained indicate that Vilon (a) induces unrolling (deheterochromatinization) of total heterochromatin; (b) activates synthetic processes caused by the reactivation of ribosomal genes as a result of deheterochromatinization of nucleolus organizer regions; (c) releases the genes repressed due to the condensation of euchromatic regions forming facultative heterochromatin; (d) does not induce decondensation of pericentromeric structural heterochromatin. Our results indicate that Vilon causes progressive activation (deheterochromatinization) of the facultative heterochromatin with increased aging.
ISSN:1389-5729
1573-6768
DOI:10.1023/B:BGEN.0000025070.90330.7f