Morphologic study of three collagen materials for body wall repair

• Published in: The Journal of surgical research 2004-05, Vol.118 (2), p.161-175
• Main Authors: Soiderer, Emily E, Lantz, Gary C, Kazacos, Evelyn A, Hodde, Jason P, Wiegand, Ryan E
• Format: Article
• Language: English
• Subjects: Abdominal Wall - pathology; Abdominal Wall - surgery; Animals; Biocompatible Materials - pharmacology; Biological and medical sciences; body wall; collagen; Collagen - pharmacology; Extracellular Matrix; Fascia - pathology; Fasciotomy; Female; General aspects; Medical sciences; Muscle, Skeletal - pathology; Muscle, Skeletal - surgery; polypropylene mesh; Polypropylenes - pharmacology; Prostheses and Implants; Rats; Rats, Sprague-Dawley; small intestinal submucosa; Surgical Mesh
• ISSN: 0022-4804; 1095-8673
• DOI: 10.1016/S0022-4804(03)00352-4

The search for ideal prostheses for body wall repair continues. Synthetic materials such as polypropylene mesh (PPM) are associated with healing complications. A porcine-derived collagen-based material (CBM), small intestinal submucosa (SIS), has been studied for body wall repair. Renal capsule matrix (RCM) and urinary bladder submucosa (UBS) are CBMs not previously evaluated in this application. This is the first implant study using RCM. Full-thickness muscle/fascia ventral abdominal wall defects were repaired with SIS, RCM, UBS, and PPM in rats with omentum and omentectomy. A random complete block design was used to allot implant type to each of 96 rats. Healing was evaluated at 4 and 8 weeks. Adhesion tenacity and surface area were scored. Implant site dimensions were measured at implantation and necropsy. Inflammation, vascularization, and fibrosis were histopathologically scored. Data were compared by analysis of variance ( P < 0.05). PPM produced a granulomatous foreign body response in contrast to the organized healing of CBM implants. CBM mean scores were lower than PPM scores for adhesion tenacity, surface area, and inflammation at each follow-up time for rats with omentums ( P < 0.02). The CBMs had less tenacity and inflammation than PPM at each follow-up time in omentectomy groups ( P < 0.008). Wound contraction was greater for PPM ( P < 0.0001) for all rats. RCM and UBS were similar to SIS invoking reduced inflammation, adhesion, and contraction compared to PPM. The fibrotic response to PPM was unique and more intense compared to CBMs. These CBM implants appear morphologically acceptable and warrant continued investigation.