New β-Caryophyllene-Derived Terpenoids from the Soft Coral Sinularia nanolobata

• Published in: Journal of natural products (Washington, D.C.) D.C.), 2004-04, Vol.67 (4), p.592-597
• Main Authors: AHMED, Atallah F., SU, Jui-Hsin, SHIUE, Ru-Ting, PAN, Xin-Jie, DAI, Chang-Feng, KUO, Yao-Haur, SHEU, Jyh-Horng
• Format: Article
• Language: English
• Subjects: Alcyonaria; Animals; Anthozoa - chemistry; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Biological and medical sciences; Diterpenes - chemistry; Diterpenes - isolation & purification; Diterpenes - pharmacology; Drug Screening Assays, Antitumor; General pharmacology; Humans; KB Cells; Marine; Medical sciences; Molecular Structure; Oceans and Seas; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Sesquiterpenes - chemistry; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology; Sinularia nanolobata; Taiwan; Tumor Cells, Cultured
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np030286w

Two new norsesquiterpenoids, nanonorcaryophyllenes A (1) and B (2), two new diterpenoids, nanolobatins A (3) and B (4), and a novel norditerpenoid, nanolobatin C (5), were isolated from the n-hexane extract of the Taiwanese soft coral Sinularia nanolobata. Also, two new furanone derivatives, 6 and 7, were isolated for the first time from natural sources. The structures of 1-5 were elucidated on the basis of extensive spectroscopic analyses and by comparison of the spectral data with those of the related metabolites. Nanonorcaryophyllenes A (1) and B (2) were characterized as 13-norcaryophyllenes that lack a methyl group at C-11, while nanolobatin C (5) represents the first example of a xeniaphyllane-based 17-norditerpenoid. The cytotoxicity of 1-6 against the growth of a limited panel of cancer cell lines is also described.