Pathologic fear conditioning and anorexia nervosa: On the search for novel paradigms

Although eating disorders have been the focus of an unprecedented explosion of clinical interest in recent years, the etiology of anorexia nervosa remains elusive. It is hypothesized that an underlying causative mechanism involves a propensity to extreme fear conditioning and greater than normal res...

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Bibliographic Details
Published in:The International journal of eating disorders 2004-05, Vol.35 (4), p.504-508
Main Author: Strober, Michael
Format: Article
Language:English
Subjects:
Adolescent
anorexia nervosa
Anorexia Nervosa - etiology
Anorexia Nervosa - psychology
Conditioning (Psychology)
Fear
fear conditioning
Female
Humans
novel paradigms
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Summary:Although eating disorders have been the focus of an unprecedented explosion of clinical interest in recent years, the etiology of anorexia nervosa remains elusive. It is hypothesized that an underlying causative mechanism involves a propensity to extreme fear conditioning and greater than normal resistance to its extinction. Knowledge accrued from recent behavioral, genetic, and neuroanatomic research on anxiety may yield further insight into the pathogenesis of anorexia nervosa, which can be subjected to experimental validation using objective measures of classical fear conditioning and functional neuroimaging of brain structures mediating fear behavior. © 2004 by Wiley Periodicals, Inc. Int J Eat Disord 35: 504–508, 2004.
ISSN:0276-3478
1098-108X
DOI:10.1002/eat.20029