MUC4 expression increases progressively in pancreatic intraepithelial neoplasia

Pancreatic adenocarcinoma is believed to develop from histologically identifiable intraductal lesions known as pancreatic intraepithelial neoplasias (PanINs) that undergo a series of architectural, cytologic, and genetic changes, a progression model similar to the adenoma-carcinoma sequence in the c...

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Bibliographic Details
Published in:American journal of clinical pathology 2002-05, Vol.117 (5), p.791-796
Main Authors: SWARTZ, Michael J, BATRA, Surinder K, VARSHNEY, Grish C, HOLLINGSWORTH, Michael A, YEO, Charles J, CAMERON, John L, WILENTZ, Robb E, HRUBAN, Ralph H, ARGANI, Pedram
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers, Tumor - metabolism
Carcinoma in Situ - metabolism
Carcinoma in Situ - pathology
Carcinoma, Pancreatic Ductal - metabolism
Carcinoma, Pancreatic Ductal - pathology
Cell Count
Disease Progression
Fluorescent Antibody Technique, Indirect
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunohistochemistry
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Mucin-4
Mucins - metabolism
Pancreatic Ducts - anatomy & histology
Pancreatic Ducts - metabolism
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - pathology
Tumors
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Summary:Pancreatic adenocarcinoma is believed to develop from histologically identifiable intraductal lesions known as pancreatic intraepithelial neoplasias (PanINs) that undergo a series of architectural, cytologic, and genetic changes, a progression model similar to the adenoma-carcinoma sequence in the colon. The apomucin MUC4 has been implicated in invasive pancreatic adenocarcinoma. MUC4 expression is not detectable at the RNA level in normal pancreas but is detectable at high levels in invasive pancreatic adenocarcinoma. We documented the pattern of expression of MUC4 in PanINs by studying a series of 71 PanIN lesions immunohistochemically using a new monoclonal antibody to MUC4. Five (17%) of 30 PanIN-1 lesions, 10 (36%) of 28 PanIN-2 lesions, 11 (85%) of 13 PanIN-3 lesions, and 25 (89%) of 28 invasive adenocarcinomas labeled with the MUC4 antibody used in the study. In addition, afew nonneoplastic lesions labeled with the MUC4 antibody, including reactive ducts in chronic pancreatitis, atrophic ducts filled with inspissated secretions, and ducts showing squamous metaplasia. Our data help establish the patterns of MUC4 expression in neoplastic precursors in the pancreas and add further support to the progression model for pancreatic adenocarcinoma.
ISSN:0002-9173
1943-7722
DOI:10.1309/7Y7N-M1WM-R0YK-M2VA