A Genome Scan for Loci Associated with Aerobic Running Capacity in Rats

Aerobic capacity is a complex trait that defines the efficiency to use atmospheric oxygen as an electron acceptor in energy transfer. Copenhagen (COP) and DA inbred rat strains show a wide difference in a test for aerobic treadmill running and serve as contrasting genetic models for aerobic capacity...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 2002-07, Vol.80 (1), p.13-20
Main Authors: Ways, Justin A, Cicila, George T, Garrett, Michael R, Koch, Lauren Gerard
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Body Weight
Classical genetics, quantitative genetics, hybrids
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Heart - anatomy & histology
Male
Microsatellite Repeats
Organ Size
Oxygen Consumption
Phenotype
Physical Conditioning, Animal
Physical Endurance - genetics
Polymorphism, Genetic
Quantitative Trait Loci
Rats
Running
Vertebrata
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Summary:Aerobic capacity is a complex trait that defines the efficiency to use atmospheric oxygen as an electron acceptor in energy transfer. Copenhagen (COP) and DA inbred rat strains show a wide difference in a test for aerobic treadmill running and serve as contrasting genetic models for aerobic capacity. A genome scan was carried out on an F2(COP×DA) segregating population (n=224) to detect quantitative trait loci (QTLs) associated with aerobic running capacity. Linkage analysis revealed a significant QTL on chromosome 16 (lod score, 4.0). A suggestive linkage was found near the p-terminus of chromosome 3 (lod score, 2.2) with evidence of an interaction with another QTL on chromosome 16 (lod score, 2.9). All three QTLs showed a dominant mode of inheritance in which the presence of at least one DA allele was associated with a greater distance run. These results represent the first aerobic capacity QTLs identified in genetic models.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.2002.6797