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Predictors of developmental disabilities after open heart surgery in young children with congenital heart defects
Objectives: To determine the prevalence of persistent developmental impairments in children with congenital heart defects and to identify factors that enhance risk for an adverse outcome. Study design: Eligible infants (n = 131)
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| Published in: | The Journal of pediatrics 2002-07, Vol.141 (1), p.51-58 |
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| Main Authors: | , , , , , , |
| Format: | Article |
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| cited_by | cdi_FETCH-LOGICAL-c373t-ea4e3060c522d355203b4636bb5a6629eb46a67d14ab150bdd4af9bb4ca6910a3 |
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| cites | cdi_FETCH-LOGICAL-c373t-ea4e3060c522d355203b4636bb5a6629eb46a67d14ab150bdd4af9bb4ca6910a3 |
| container_end_page | 58 |
| container_issue | 1 |
| container_start_page | 51 |
| container_title | The Journal of pediatrics |
| container_volume | 141 |
| creator | Limperopoulos, Catherine Majnemer, Annette Shevell, Michael I. Rohlicek, Charles Rosenblatt, Bernard Tchervenkov, Christo Darwish, H.Z. |
| description | Objectives: To determine the prevalence of persistent developmental impairments in children with congenital heart defects and to identify factors that enhance risk for an adverse outcome. Study design: Eligible infants (n = 131) |
| doi_str_mv | 10.1067/mpd.2002.125227 |
| format | article |
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Study design: Eligible infants (n = 131) <2 years of age requiring open heart surgery were recruited prospectively. Subjects were assessed during surgery and again 12 to 18 months later with standardized developmental assessments and formal neurologic examinations. Results: Mean age at follow-up testing was 19.1 ± 6.6 months. Assessments indicated that 41% had abnormal neurologic examinations. Gross and/or fine motor delays were documented in 42%, and 23% demonstrated global developmental delay. Univariate and multiple regression models identified the following factors increasing the risk for persistent developmental deficits: preoperative and acute postoperative neurodevelopmental status and microcephaly, type of heart lesion, length of deep hypothermic circulatory arrest, age at surgery, and days in the intensive care unit (P <.05). Conclusions: Children with congenital heart defects commonly have ongoing neurologic, motor, and developmental deficits well after surgical correction. The cause is multifactorial and includes brain injury before, during, and after heart surgery. (J Pediatr 2002;141:51-8)</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1067/mpd.2002.125227</identifier><identifier>PMID: 12091851</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Abnormalities, Multiple ; Biological and medical sciences ; Cardiopulmonary Bypass ; Developmental Disabilities - epidemiology ; Heart Defects, Congenital - surgery ; Humans ; Infant ; Infant, Newborn ; Linear Models ; Medical sciences ; Microcephaly ; Motor Skills Disorders - epidemiology ; Multivariate Analysis ; Postoperative Complications - epidemiology ; Prevalence ; Prospective Studies ; Quebec - epidemiology ; Risk ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><ispartof>The Journal of pediatrics, 2002-07, Vol.141 (1), p.51-58</ispartof><rights>2002</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-ea4e3060c522d355203b4636bb5a6629eb46a67d14ab150bdd4af9bb4ca6910a3</citedby><cites>FETCH-LOGICAL-c373t-ea4e3060c522d355203b4636bb5a6629eb46a67d14ab150bdd4af9bb4ca6910a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13798494$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12091851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Limperopoulos, Catherine</creatorcontrib><creatorcontrib>Majnemer, Annette</creatorcontrib><creatorcontrib>Shevell, Michael I.</creatorcontrib><creatorcontrib>Rohlicek, Charles</creatorcontrib><creatorcontrib>Rosenblatt, Bernard</creatorcontrib><creatorcontrib>Tchervenkov, Christo</creatorcontrib><creatorcontrib>Darwish, H.Z.</creatorcontrib><title>Predictors of developmental disabilities after open heart surgery in young children with congenital heart defects</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objectives: To determine the prevalence of persistent developmental impairments in children with congenital heart defects and to identify factors that enhance risk for an adverse outcome. Study design: Eligible infants (n = 131) <2 years of age requiring open heart surgery were recruited prospectively. Subjects were assessed during surgery and again 12 to 18 months later with standardized developmental assessments and formal neurologic examinations. Results: Mean age at follow-up testing was 19.1 ± 6.6 months. Assessments indicated that 41% had abnormal neurologic examinations. Gross and/or fine motor delays were documented in 42%, and 23% demonstrated global developmental delay. Univariate and multiple regression models identified the following factors increasing the risk for persistent developmental deficits: preoperative and acute postoperative neurodevelopmental status and microcephaly, type of heart lesion, length of deep hypothermic circulatory arrest, age at surgery, and days in the intensive care unit (P <.05). Conclusions: Children with congenital heart defects commonly have ongoing neurologic, motor, and developmental deficits well after surgical correction. The cause is multifactorial and includes brain injury before, during, and after heart surgery. (J Pediatr 2002;141:51-8)</description><subject>Abnormalities, Multiple</subject><subject>Biological and medical sciences</subject><subject>Cardiopulmonary Bypass</subject><subject>Developmental Disabilities - epidemiology</subject><subject>Heart Defects, Congenital - surgery</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Linear Models</subject><subject>Medical sciences</subject><subject>Microcephaly</subject><subject>Motor Skills Disorders - epidemiology</subject><subject>Multivariate Analysis</subject><subject>Postoperative Complications - epidemiology</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Quebec - epidemiology</subject><subject>Risk</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNp1kU1r3DAQhkVpaDZpz70VXZqbN_qyvD6WkLSFQHtoz0If410VW3IkOWX_fbR4IaecxDCP3hk9QugzJVtKZHc7zW7LCGFbylrGundoQ0nfNXLH-Xu0qQ3WcNHJS3SV8z9CSC8I-YAuKSM93bV0g55-J3DelpgyjgN28AxjnCcIRY_Y-ayNH33xkLEeCiQcZwj4ADoVnJe0h3TEPuBjXMIe24MfXar9_74csI1hD8GfclbewQC25I_oYtBjhk_n8xr9fbj_c_ejefz1_efdt8fG8o6XBrQATiSx9V2Oty0j3AjJpTGtlpL1UCstO0eFNrQlxjmhh94YYbXsKdH8Gt2suXOKTwvkoiafLYyjDhCXrDq6k1WZqODtCtoUc04wqDn5SaejokSdLKtqWZ0sq9VyvfHlHL2YCdwrf9Zaga9nQGerxyHpYH1-5XjX70R_Gt2vHFQRzx6SytZDsPVLUnWlXPRvLvECa32anA</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>Limperopoulos, Catherine</creator><creator>Majnemer, Annette</creator><creator>Shevell, Michael I.</creator><creator>Rohlicek, Charles</creator><creator>Rosenblatt, Bernard</creator><creator>Tchervenkov, Christo</creator><creator>Darwish, H.Z.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020701</creationdate><title>Predictors of developmental disabilities after open heart surgery in young children with congenital heart defects</title><author>Limperopoulos, Catherine ; Majnemer, Annette ; Shevell, Michael I. ; Rohlicek, Charles ; Rosenblatt, Bernard ; Tchervenkov, Christo ; Darwish, H.Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-ea4e3060c522d355203b4636bb5a6629eb46a67d14ab150bdd4af9bb4ca6910a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Abnormalities, Multiple</topic><topic>Biological and medical sciences</topic><topic>Cardiopulmonary Bypass</topic><topic>Developmental Disabilities - epidemiology</topic><topic>Heart Defects, Congenital - surgery</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Linear Models</topic><topic>Medical sciences</topic><topic>Microcephaly</topic><topic>Motor Skills Disorders - epidemiology</topic><topic>Multivariate Analysis</topic><topic>Postoperative Complications - epidemiology</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Quebec - epidemiology</topic><topic>Risk</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Limperopoulos, Catherine</creatorcontrib><creatorcontrib>Majnemer, Annette</creatorcontrib><creatorcontrib>Shevell, Michael I.</creatorcontrib><creatorcontrib>Rohlicek, Charles</creatorcontrib><creatorcontrib>Rosenblatt, Bernard</creatorcontrib><creatorcontrib>Tchervenkov, Christo</creatorcontrib><creatorcontrib>Darwish, H.Z.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Limperopoulos, Catherine</au><au>Majnemer, Annette</au><au>Shevell, Michael I.</au><au>Rohlicek, Charles</au><au>Rosenblatt, Bernard</au><au>Tchervenkov, Christo</au><au>Darwish, H.Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of developmental disabilities after open heart surgery in young children with congenital heart defects</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>141</volume><issue>1</issue><spage>51</spage><epage>58</epage><pages>51-58</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Objectives: To determine the prevalence of persistent developmental impairments in children with congenital heart defects and to identify factors that enhance risk for an adverse outcome. Study design: Eligible infants (n = 131) <2 years of age requiring open heart surgery were recruited prospectively. Subjects were assessed during surgery and again 12 to 18 months later with standardized developmental assessments and formal neurologic examinations. Results: Mean age at follow-up testing was 19.1 ± 6.6 months. Assessments indicated that 41% had abnormal neurologic examinations. Gross and/or fine motor delays were documented in 42%, and 23% demonstrated global developmental delay. Univariate and multiple regression models identified the following factors increasing the risk for persistent developmental deficits: preoperative and acute postoperative neurodevelopmental status and microcephaly, type of heart lesion, length of deep hypothermic circulatory arrest, age at surgery, and days in the intensive care unit (P <.05). Conclusions: Children with congenital heart defects commonly have ongoing neurologic, motor, and developmental deficits well after surgical correction. The cause is multifactorial and includes brain injury before, during, and after heart surgery. (J Pediatr 2002;141:51-8)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>12091851</pmid><doi>10.1067/mpd.2002.125227</doi><tpages>8</tpages></addata></record> |
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| ispartof | The Journal of pediatrics, 2002-07, Vol.141 (1), p.51-58 |
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| language | eng |
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| source | ScienceDirect Journals |
| subjects | Abnormalities, Multiple Biological and medical sciences Cardiopulmonary Bypass Developmental Disabilities - epidemiology Heart Defects, Congenital - surgery Humans Infant Infant, Newborn Linear Models Medical sciences Microcephaly Motor Skills Disorders - epidemiology Multivariate Analysis Postoperative Complications - epidemiology Prevalence Prospective Studies Quebec - epidemiology Risk Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels |
| title | Predictors of developmental disabilities after open heart surgery in young children with congenital heart defects |
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