Pathogenesis and pathology of hematogenous infections of the fetus and newborn

The earlier infections occur in intrauterine life the more severe are they. When the infection develops during embryogenesis, the lesions are much more serious, sometimes causing disruptions (malformations). At this time the organs are not completely formed and microorganisms may interfere with orga...

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Bibliographic Details
Published in:Pediatric pathology & molecular medicine 2002-07, Vol.21 (4), p.353-399
Main Authors: Bittencourt, Achiléa Lisboa, Garcia, Aparecida Gomes Pinto
Format: Article
Language:English
Subjects:
Abnormalities, Multiple - etiology
Bacterial Infections - congenital
Bacterial Infections - pathology
Female
Fetal Death
Fetal Diseases - etiology
Fetal Diseases - pathology
Fetal Growth Retardation
Fetus - pathology
Gestational Age
Humans
Infant, Newborn
Pregnancy
Pregnancy Complications, Infectious
Protozoan Infections - congenital
Protozoan Infections - pathology
Virus Diseases - congenital
Virus Diseases - pathology
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Summary:The earlier infections occur in intrauterine life the more severe are they. When the infection develops during embryogenesis, the lesions are much more serious, sometimes causing disruptions (malformations). At this time the organs are not completely formed and microorganisms may interfere with organogenesis to such an extent that the development of the functions necessary for viability become impaired. Infection acquired in utero may result in resorption of the embryo, abortion, stillbirth, neonatal death, intrauterine growth retardation (IUGR), or prematurity. The infected newborns commonly are apparently normal at birth but they may develop a late onset disease. Otherwise, neonates presenting symptomatology may derelop untoward sequelae.
ISSN:1522-7952
1521-4525
DOI:10.1080/152279502760157759