Psychoneuroimmunology: Psychological Influences on Immune Function and Health

This review focuses on human psychoneuroimmunology studies published in the past decade. Issues discussed include the routes through which psychological factors influence immune function, how a stressor's duration may influence the changes observed, individual difference variables, the ability...

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Bibliographic Details
Published in:Journal of consulting and clinical psychology 2002-06, Vol.70 (3), p.537-547
Main Authors: Kiecolt-Glaser, Janice K, McGuire, Lynanne, Robles, Theodore F, Glaser, Ronald
Format: Article
Language:English
Subjects:
Health
Health Promotion
Health Status
Human
Humans
Immune System - physiology
Immunology
Individual Differences
Interleukins - immunology
Psychological Stress
Psychology
Psychoneuroimmunology
Psychoneuroimmunology - methods
Psychosocial Factors
Stress, Psychological - immunology
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Summary:This review focuses on human psychoneuroimmunology studies published in the past decade. Issues discussed include the routes through which psychological factors influence immune function, how a stressor's duration may influence the changes observed, individual difference variables, the ability of interventions to modulate immune function, and the health consequences of psychosocially mediated immune dysregulation. The importance of negative affect and supportive personal relationships are highlighted. Recent data suggest that immune dysregulation may be one core mechanism for a spectrum of conditions associated with aging, including cardiovascular disease, osteoporosis, arthritis, Type 2 diabetes, certain cancers, and frailty and functional decline; production of proinflammatory cytokines that influence these and other conditions can be stimulated directly by negative emotions and indirectly by prolonged infection.
ISSN:0022-006X
1939-2117
DOI:10.1037/0022-006X.70.3.537