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Myocardial blood flow and efficiency in concentric and eccentric left ventricular hypertrophy
It is not clearly understood why concentric left ventricular hypertrophy (increased left ventricular mass and relative wall thickness) is associated with higher cardiovascular risk than eccentric hypertrophy (increased left ventricular mass but normal relative wall thickness). Possible reasons inclu...
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| Published in: | American journal of hypertension 2004-05, Vol.17 (5), p.433-438 |
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| container_end_page | 438 |
| container_issue | 5 |
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| container_title | American journal of hypertension |
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| creator | Akinboboye, Olakunle O. Chou, Ru-Ling Bergmann, Steven R. |
| description | It is not clearly understood why concentric left ventricular hypertrophy (increased left ventricular mass and relative wall thickness) is associated with higher cardiovascular risk than eccentric hypertrophy (increased left ventricular mass but normal relative wall thickness). Possible reasons include lower myocardial efficiency or perfusion reserve in concentric than in eccentric hypertrophy. We compared myocardial perfusion reserve and efficiency in normotensive controls and in hypertensive patients with concentric and with eccentric hypertrophy.
Study subjects comprised 16 patients with hypertension-induced left ventricular hypertrophy and 10 normotensive controls. We measured myocardial perfusion reserve and oxygen consumption by positron emission tomography. We calculated myocardial efficiency by dividing left ventricular minute work by myocardial oxygen consumption.
There was no significant difference in myocardial perfusion reserve between patients with concentric (
n = 9) as compared to eccentric (
n = 7) hypertrophy. However, myocardial perfusion reserve in both patient groups were lower than in controls. Although myocardial efficiency in patients with eccentric hypertrophy and in controls were not different, both values were higher than measurements in patients with concentric hypertrophy (18% ± 6%
v 16% ± 3%
v 13% ± 4%, eccentric hypertrophy versus controls versus concentric hypertrophy, respectively,
P = .04 for both eccentric versus concentric hypertrophy and for controls versus concentric hypertrophy).
Myocardial efficiency but not perfusion reserve is lower in hearts with concentric compared with eccentric left ventricular hypertrophy. This might be an explanation for the higher cardiovascular morbidity and mortality associated with concentric left ventricular hypertrophy. |
| doi_str_mv | 10.1016/j.amjhyper.2004.02.006 |
| format | article |
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Study subjects comprised 16 patients with hypertension-induced left ventricular hypertrophy and 10 normotensive controls. We measured myocardial perfusion reserve and oxygen consumption by positron emission tomography. We calculated myocardial efficiency by dividing left ventricular minute work by myocardial oxygen consumption.
There was no significant difference in myocardial perfusion reserve between patients with concentric (
n = 9) as compared to eccentric (
n = 7) hypertrophy. However, myocardial perfusion reserve in both patient groups were lower than in controls. Although myocardial efficiency in patients with eccentric hypertrophy and in controls were not different, both values were higher than measurements in patients with concentric hypertrophy (18% ± 6%
v 16% ± 3%
v 13% ± 4%, eccentric hypertrophy versus controls versus concentric hypertrophy, respectively,
P = .04 for both eccentric versus concentric hypertrophy and for controls versus concentric hypertrophy).
Myocardial efficiency but not perfusion reserve is lower in hearts with concentric compared with eccentric left ventricular hypertrophy. This might be an explanation for the higher cardiovascular morbidity and mortality associated with concentric left ventricular hypertrophy.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1879-1905</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1016/j.amjhyper.2004.02.006</identifier><identifier>PMID: 15110903</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Age Factors ; Aged ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Cardiology. Vascular system ; Coronary Circulation - physiology ; Dipyridamole - administration & dosage ; Echocardiography ; Female ; Heart Rate - drug effects ; Heart Rate - physiology ; Humans ; Hypertrophy, Left Ventricular - diagnostic imaging ; Hypertrophy, Left Ventricular - physiopathology ; left ventricular hypertrophy ; Male ; Medical sciences ; Middle Aged ; myocardial blood flow ; myocardial oxygen demand ; Myocardial perfusion reserve ; Myocardial Reperfusion ; Myocardium - pathology ; Myocardium - ultrastructure ; Oxygen Consumption - physiology ; positron emission tomography ; Regional Blood Flow - physiology ; Statistics as Topic ; Stroke Volume - physiology ; Systole - drug effects ; Systole - physiology ; Tomography, Emission-Computed ; Vasodilator Agents - administration & dosage</subject><ispartof>American journal of hypertension, 2004-05, Vol.17 (5), p.433-438</ispartof><rights>2004 American Journal of Hypertension, Ltd.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Nature Publishing Group May 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c598t-bf9ba57d5d21f2576f88a9d7c3ddd2afd5509dff19289573ff1786e15c4b81023</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15724423$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15110903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akinboboye, Olakunle O.</creatorcontrib><creatorcontrib>Chou, Ru-Ling</creatorcontrib><creatorcontrib>Bergmann, Steven R.</creatorcontrib><title>Myocardial blood flow and efficiency in concentric and eccentric left ventricular hypertrophy</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>It is not clearly understood why concentric left ventricular hypertrophy (increased left ventricular mass and relative wall thickness) is associated with higher cardiovascular risk than eccentric hypertrophy (increased left ventricular mass but normal relative wall thickness). Possible reasons include lower myocardial efficiency or perfusion reserve in concentric than in eccentric hypertrophy. We compared myocardial perfusion reserve and efficiency in normotensive controls and in hypertensive patients with concentric and with eccentric hypertrophy.
Study subjects comprised 16 patients with hypertension-induced left ventricular hypertrophy and 10 normotensive controls. We measured myocardial perfusion reserve and oxygen consumption by positron emission tomography. We calculated myocardial efficiency by dividing left ventricular minute work by myocardial oxygen consumption.
There was no significant difference in myocardial perfusion reserve between patients with concentric (
n = 9) as compared to eccentric (
n = 7) hypertrophy. However, myocardial perfusion reserve in both patient groups were lower than in controls. Although myocardial efficiency in patients with eccentric hypertrophy and in controls were not different, both values were higher than measurements in patients with concentric hypertrophy (18% ± 6%
v 16% ± 3%
v 13% ± 4%, eccentric hypertrophy versus controls versus concentric hypertrophy, respectively,
P = .04 for both eccentric versus concentric hypertrophy and for controls versus concentric hypertrophy).
Myocardial efficiency but not perfusion reserve is lower in hearts with concentric compared with eccentric left ventricular hypertrophy. This might be an explanation for the higher cardiovascular morbidity and mortality associated with concentric left ventricular hypertrophy.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Circulation - physiology</subject><subject>Dipyridamole - administration & dosage</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Hypertrophy, Left Ventricular - diagnostic imaging</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>left ventricular hypertrophy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>myocardial blood flow</subject><subject>myocardial oxygen demand</subject><subject>Myocardial perfusion reserve</subject><subject>Myocardial Reperfusion</subject><subject>Myocardium - pathology</subject><subject>Myocardium - ultrastructure</subject><subject>Oxygen Consumption - physiology</subject><subject>positron emission tomography</subject><subject>Regional Blood Flow - physiology</subject><subject>Statistics as Topic</subject><subject>Stroke Volume - physiology</subject><subject>Systole - drug effects</subject><subject>Systole - physiology</subject><subject>Tomography, Emission-Computed</subject><subject>Vasodilator Agents - administration & dosage</subject><issn>0895-7061</issn><issn>1879-1905</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqF0U2P1CAYB3BiNO64-hXWJkZvrUDL202zUcdkVw9qYjYxhPKSoXbKCO1qv710O-saL56A8OPh4Q8AZwhWCCL6sqvUvtvNBxsrDGFTQVxBSO-BDeJMlEhAch9sIBekZJCiE_AopQ5mSCl6CE4QQQgKWG_At8s5aBWNV33R9iGYwvXhZ6EGU1jnvPZ20HPhh0KHQdthjF6vm_p21Vs3FtfrYupVLG66GmM47ObH4IFTfbJPjuMp-PL2zefzbXnx8d3789cXpSaCj2XrRKsIM8Rg5DBh1HGuhGG6NsZg5QwhUBjnkMD5RazOM8apRUQ3LUcQ16fgxVr3EMOPyaZR7n3Stu_VYMOUJEOcNlQs8Nk_sAtTHHJvMtehpKENoVnRVekYUorWyUP0exXnjOQSv-zkbfxyiV9CLHP8-eDZsfzU7q25O3bMO4PnR6CSVr2LatA-_eUYbhq8uKerG9Q4RfsHqG633MdRFuUqfBrtrzsQv0vKakbk9uuV_HR1ySDfCvkh-1ert_kfrn1uPN18rjU-Wj1KE_z_XvcbJGzBZA</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Akinboboye, Olakunle O.</creator><creator>Chou, Ru-Ling</creator><creator>Bergmann, Steven R.</creator><general>Elsevier Inc</general><general>Oxford University Press</general><general>Elsevier Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>Myocardial blood flow and efficiency in concentric and eccentric left ventricular hypertrophy</title><author>Akinboboye, Olakunle O. ; Chou, Ru-Ling ; Bergmann, Steven R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c598t-bf9ba57d5d21f2576f88a9d7c3ddd2afd5509dff19289573ff1786e15c4b81023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Circulation - physiology</topic><topic>Dipyridamole - administration & dosage</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Hypertrophy, Left Ventricular - diagnostic imaging</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>left ventricular hypertrophy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>myocardial blood flow</topic><topic>myocardial oxygen demand</topic><topic>Myocardial perfusion reserve</topic><topic>Myocardial Reperfusion</topic><topic>Myocardium - pathology</topic><topic>Myocardium - ultrastructure</topic><topic>Oxygen Consumption - physiology</topic><topic>positron emission tomography</topic><topic>Regional Blood Flow - physiology</topic><topic>Statistics as Topic</topic><topic>Stroke Volume - physiology</topic><topic>Systole - drug effects</topic><topic>Systole - physiology</topic><topic>Tomography, Emission-Computed</topic><topic>Vasodilator Agents - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akinboboye, Olakunle O.</creatorcontrib><creatorcontrib>Chou, Ru-Ling</creatorcontrib><creatorcontrib>Bergmann, Steven R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akinboboye, Olakunle O.</au><au>Chou, Ru-Ling</au><au>Bergmann, Steven R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial blood flow and efficiency in concentric and eccentric left ventricular hypertrophy</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>17</volume><issue>5</issue><spage>433</spage><epage>438</epage><pages>433-438</pages><issn>0895-7061</issn><eissn>1879-1905</eissn><eissn>1941-7225</eissn><coden>AJHYE6</coden><abstract>It is not clearly understood why concentric left ventricular hypertrophy (increased left ventricular mass and relative wall thickness) is associated with higher cardiovascular risk than eccentric hypertrophy (increased left ventricular mass but normal relative wall thickness). Possible reasons include lower myocardial efficiency or perfusion reserve in concentric than in eccentric hypertrophy. We compared myocardial perfusion reserve and efficiency in normotensive controls and in hypertensive patients with concentric and with eccentric hypertrophy.
Study subjects comprised 16 patients with hypertension-induced left ventricular hypertrophy and 10 normotensive controls. We measured myocardial perfusion reserve and oxygen consumption by positron emission tomography. We calculated myocardial efficiency by dividing left ventricular minute work by myocardial oxygen consumption.
There was no significant difference in myocardial perfusion reserve between patients with concentric (
n = 9) as compared to eccentric (
n = 7) hypertrophy. However, myocardial perfusion reserve in both patient groups were lower than in controls. Although myocardial efficiency in patients with eccentric hypertrophy and in controls were not different, both values were higher than measurements in patients with concentric hypertrophy (18% ± 6%
v 16% ± 3%
v 13% ± 4%, eccentric hypertrophy versus controls versus concentric hypertrophy, respectively,
P = .04 for both eccentric versus concentric hypertrophy and for controls versus concentric hypertrophy).
Myocardial efficiency but not perfusion reserve is lower in hearts with concentric compared with eccentric left ventricular hypertrophy. This might be an explanation for the higher cardiovascular morbidity and mortality associated with concentric left ventricular hypertrophy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15110903</pmid><doi>10.1016/j.amjhyper.2004.02.006</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of hypertension, 2004-05, Vol.17 (5), p.433-438 |
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| subjects | Adult Age Factors Aged Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Blood Pressure - physiology Cardiology. Vascular system Coronary Circulation - physiology Dipyridamole - administration & dosage Echocardiography Female Heart Rate - drug effects Heart Rate - physiology Humans Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - physiopathology left ventricular hypertrophy Male Medical sciences Middle Aged myocardial blood flow myocardial oxygen demand Myocardial perfusion reserve Myocardial Reperfusion Myocardium - pathology Myocardium - ultrastructure Oxygen Consumption - physiology positron emission tomography Regional Blood Flow - physiology Statistics as Topic Stroke Volume - physiology Systole - drug effects Systole - physiology Tomography, Emission-Computed Vasodilator Agents - administration & dosage |
| title | Myocardial blood flow and efficiency in concentric and eccentric left ventricular hypertrophy |
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