The control of Staphylococcus epidermidis biofilm formation and in vivo infection rates by covalently bound furanones

In order to overcome the continuing infection rate associated with biomaterials, the use of covalently bound furanones as an antibiofilm coating for biomaterials has been investigated. Furanones have previously been shown to inhibit growth of Gram-positive and Gram-negative bacteria. The aim of thes...

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Bibliographic Details
Published in:Biomaterials 2004-09, Vol.25 (20), p.5023-5030
Main Authors: Hume, E.B.H., Baveja, J., Muir, B., Schubert, T.L., Kumar, N., Kjelleberg, S., Griesser, H.J., Thissen, H., Read, R., Poole-Warren, L.A., Schindhelm, K., Willcox, M.D.P.
Format: Article
Language:English
Subjects:
Animals
Antibacterial
Bacteria
Bacterial Adhesion
Biocompatible Materials
Biofilm
Biofilms
Biopolymers
Catheter
Catheterization
Ethyldimethylaminopropyl Carbodiimide - chemistry
Furans - chemistry
In vivo test
Polymers - chemistry
Polystyrenes - chemistry
Protein Binding
Sheep
Staphylococcal Infections - metabolism
Staphylococcus epidermidis
Staphylococcus epidermidis - metabolism
Time Factors
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Summary:In order to overcome the continuing infection rate associated with biomaterials, the use of covalently bound furanones as an antibiofilm coating for biomaterials has been investigated. Furanones have previously been shown to inhibit growth of Gram-positive and Gram-negative bacteria. The aim of these studies were to covalently bind furanones to polymers and to test their efficacy for inhibiting biofilm formation of Staphylococcus epidermidis and in vivo infection rate . Two methods of covalent attachment of furanones were used. The first, a co-polymerisation with a styrene polymer, and second, a plasma-1-ethyl-3-(dimethylaminopropyl) carbodiimide (EDC) reaction to produce furanone-coated catheters. Biofilm formation by S. epidermidis in vitro was inhibited by 89% for polystryene–furanone disks and by 78% by furanone-coated catheters ( p
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2004.01.048