Bone mass, bone metabolism, gonadal status and body mass index

Weight and gonadal status are the main determinants of bone mass in women. Because of this it is important to study which influences it more. The effect of weight (expressed as body mass index, BMI) and gonadal status of women on total-body bone mineral content (TBBMC) and regional bone mineral cont...

Full description

Saved in:
Bibliographic Details
Published in:Osteoporosis international 2002-05, Vol.13 (5), p.379-387
Main Authors: RICO, H, ARRIBAS, I, CASANOVA, F. J, DUCE, A. M, HERNANDEZ, E. R, CORTES-PRIETO, J
Format: Article
Language:English
Subjects:
Absorptiometry, Photon - methods
Acid Phosphatase - analysis
Adult
Age
Age Factors
Alkaline Phosphatase - analysis
Analysis of Variance
Biological and medical sciences
Biomarkers - analysis
Body Mass Index
Body Weight
Bone and Bones - physiology
Bone Density - physiology
Bones
Female
Fundamental and applied biological sciences. Psychology
Health care
Humans
Isoenzymes - analysis
Measurement techniques
Menopause
Menopause - physiology
Menstruation
Metabolism
Middle Aged
Obesity
Osteoporosis
Overweight
Phosphatase
Postmenopause - physiology
Premenopause - physiology
Public health
Regression Analysis
Skeleton and joints
Steroids
Tartrate-Resistant Acid Phosphatase
Vertebrates: osteoarticular system, musculoskeletal system
Weight-Bearing
Womens health
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Weight and gonadal status are the main determinants of bone mass in women. Because of this it is important to study which influences it more. The effect of weight (expressed as body mass index, BMI) and gonadal status of women on total-body bone mineral content (TBBMC) and regional bone mineral content (BMC) was investigated. A total of 373 normal women (mean age 48.9 +/- 13.4 years) were studied: 171 postmenopausal women (mean age 59.3 +/- 9.5 years; years since menopause 11.3 +/- 6.7 years); 76 perimenopausal women (mean age 48.9 +/- 2.2 years); and 126 premenopausal women (mean age 34.7 +/- 7.4 years). In all the women, TBBMC and regional BMC were determined by dual-energy X-ray absorptiometry. Also biochemical markers of bone metabolism (total alkaline phosphatase and tartrate-resistant acid phosphatase) and serum estrone and estradiol were determined. When the women were stratified by gonadal status and BMI, thin women (BMI 30 kg/m2) women, regardless of gonadal status. Overweight and obese women had findings suggestive of increased parathyroid activity, but greater bone mass. Weight rather than gonadal steroid concentration is the main determinant of bone mass in women regardless of gonadal status.
ISSN:0937-941X
1433-2965
DOI:10.1007/s001980200043