Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors

Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure–activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P 1, synth...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2004-05, Vol.14 (10), p.2499-2503
Main Authors: Lim, Hyun-Suk, Park, Jeong-Ju, Ko, Kwangseok, Lee, Mee-Hyun, Chung, Sung-Kee
Format: Article
Language:English
Subjects:
Animals
Binding Sites
Biological and medical sciences
Cell Line
EDG/S1P receptors
Humans
Ligands
Lysophospholipids - chemistry
Medical sciences
Miscellaneous
Models, Molecular
Pharmacology. Drug treatments
Protein Binding
Radioligand Assay
Receptors, Lysosphingolipid - chemistry
Relative binding affinities
Sphingosine - analogs & derivatives
Sphingosine - chemistry
Sphingosine-1-phosphate analogues
Structural Homology, Protein
Structure-Activity Relationship
Structure–activity relationships
Transfection
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Summary:Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure–activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P 1, syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors. Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure–activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P 1, syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2004.03.001