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Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors
Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure–activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P 1, synth...
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| Published in: | Bioorganic & medicinal chemistry letters 2004-05, Vol.14 (10), p.2499-2503 |
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| Main Authors: | , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c382t-407907751c6357e64ac4e4ae2513c0f0eae8e5323964793ba41b9535787b48693 |
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| cites | cdi_FETCH-LOGICAL-c382t-407907751c6357e64ac4e4ae2513c0f0eae8e5323964793ba41b9535787b48693 |
| container_end_page | 2503 |
| container_issue | 10 |
| container_start_page | 2499 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 14 |
| creator | Lim, Hyun-Suk Park, Jeong-Ju Ko, Kwangseok Lee, Mee-Hyun Chung, Sung-Kee |
| description | Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure–activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P
1, syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors.
Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure–activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P
1, syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors. |
| doi_str_mv | 10.1016/j.bmcl.2004.03.001 |
| format | article |
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1, syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors.
Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure–activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P
1, syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2004.03.001</identifier><identifier>PMID: 15109640</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Binding Sites ; Biological and medical sciences ; Cell Line ; EDG/S1P receptors ; Humans ; Ligands ; Lysophospholipids - chemistry ; Medical sciences ; Miscellaneous ; Models, Molecular ; Pharmacology. Drug treatments ; Protein Binding ; Radioligand Assay ; Receptors, Lysosphingolipid - chemistry ; Relative binding affinities ; Sphingosine - analogs & derivatives ; Sphingosine - chemistry ; Sphingosine-1-phosphate analogues ; Structural Homology, Protein ; Structure-Activity Relationship ; Structure–activity relationships ; Transfection</subject><ispartof>Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (10), p.2499-2503</ispartof><rights>2004 Elsevier Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-407907751c6357e64ac4e4ae2513c0f0eae8e5323964793ba41b9535787b48693</citedby><cites>FETCH-LOGICAL-c382t-407907751c6357e64ac4e4ae2513c0f0eae8e5323964793ba41b9535787b48693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15707774$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15109640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lim, Hyun-Suk</creatorcontrib><creatorcontrib>Park, Jeong-Ju</creatorcontrib><creatorcontrib>Ko, Kwangseok</creatorcontrib><creatorcontrib>Lee, Mee-Hyun</creatorcontrib><creatorcontrib>Chung, Sung-Kee</creatorcontrib><title>Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure–activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P
1, syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors.
Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure–activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P
1, syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors.</description><subject>Animals</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>EDG/S1P receptors</subject><subject>Humans</subject><subject>Ligands</subject><subject>Lysophospholipids - chemistry</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Models, Molecular</subject><subject>Pharmacology. Drug treatments</subject><subject>Protein Binding</subject><subject>Radioligand Assay</subject><subject>Receptors, Lysosphingolipid - chemistry</subject><subject>Relative binding affinities</subject><subject>Sphingosine - analogs & derivatives</subject><subject>Sphingosine - chemistry</subject><subject>Sphingosine-1-phosphate analogues</subject><subject>Structural Homology, Protein</subject><subject>Structure-Activity Relationship</subject><subject>Structure–activity relationships</subject><subject>Transfection</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp9kMFqGzEQhkVJqB23L9BD2Uty281opV3tQi_FSdyCIYE0EOhBaOVZW2YtbSW5IW8fGRvaU04DM98M_3yEfKFQUKD19bbodnooSgBeACsA6AcypbzmOeNQnZEptDXkTcufJ-QihG0COHD-kUxoRdOMw5T8fny1cYMBQ-b6LIwbY9cuGIs5zceNSw0VMVNWDW69T5CyqyzxxmfGRvRKR-Ns9mLiJru9WVw_0ofMo8YxOh8-kfNeDQE_n-qMPN3d_pr_yJf3i5_z78tcs6aMOQfRghAV1TWrBNZcaY5cYVlRpqEHVNhgxUqWEouWdYrTrq0S2oiON3XLZuTqeHf07k8KGeXOBI3DoCy6fZCCNnXVAEtgeQS1dyF47OXozU75V0lBHpTKrTwolQelEphMxtLS19P1fbfD1b-Vk8MEXJ4AFbQaeq-sNuE_TqTvBE_ctyOHycVfg14GbdBqXJmkLMqVM-_leAMTxpN3</recordid><startdate>20040517</startdate><enddate>20040517</enddate><creator>Lim, Hyun-Suk</creator><creator>Park, Jeong-Ju</creator><creator>Ko, Kwangseok</creator><creator>Lee, Mee-Hyun</creator><creator>Chung, Sung-Kee</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040517</creationdate><title>Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors</title><author>Lim, Hyun-Suk ; Park, Jeong-Ju ; Ko, Kwangseok ; Lee, Mee-Hyun ; Chung, Sung-Kee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-407907751c6357e64ac4e4ae2513c0f0eae8e5323964793ba41b9535787b48693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>EDG/S1P receptors</topic><topic>Humans</topic><topic>Ligands</topic><topic>Lysophospholipids - chemistry</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Models, Molecular</topic><topic>Pharmacology. Drug treatments</topic><topic>Protein Binding</topic><topic>Radioligand Assay</topic><topic>Receptors, Lysosphingolipid - chemistry</topic><topic>Relative binding affinities</topic><topic>Sphingosine - analogs & derivatives</topic><topic>Sphingosine - chemistry</topic><topic>Sphingosine-1-phosphate analogues</topic><topic>Structural Homology, Protein</topic><topic>Structure-Activity Relationship</topic><topic>Structure–activity relationships</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lim, Hyun-Suk</creatorcontrib><creatorcontrib>Park, Jeong-Ju</creatorcontrib><creatorcontrib>Ko, Kwangseok</creatorcontrib><creatorcontrib>Lee, Mee-Hyun</creatorcontrib><creatorcontrib>Chung, Sung-Kee</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lim, Hyun-Suk</au><au>Park, Jeong-Ju</au><au>Ko, Kwangseok</au><au>Lee, Mee-Hyun</au><au>Chung, Sung-Kee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2004-05-17</date><risdate>2004</risdate><volume>14</volume><issue>10</issue><spage>2499</spage><epage>2503</epage><pages>2499-2503</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure–activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P
1, syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors.
Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure–activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P
1, syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15109640</pmid><doi>10.1016/j.bmcl.2004.03.001</doi><tpages>5</tpages></addata></record> |
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| ispartof | Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (10), p.2499-2503 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Animals Binding Sites Biological and medical sciences Cell Line EDG/S1P receptors Humans Ligands Lysophospholipids - chemistry Medical sciences Miscellaneous Models, Molecular Pharmacology. Drug treatments Protein Binding Radioligand Assay Receptors, Lysosphingolipid - chemistry Relative binding affinities Sphingosine - analogs & derivatives Sphingosine - chemistry Sphingosine-1-phosphate analogues Structural Homology, Protein Structure-Activity Relationship Structure–activity relationships Transfection |
| title | Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors |
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