Probing the interaction of the biotin-avidin complex with the relaxivity of biotinylated Gd-DTPA

A biotinylated Gd-DTPA complex is designed to study the biotin-avidin complexation using the longitudinal relaxivity of this new MRI label, which illustrates the use of MRI contrast agents to probe the formation of supramolecular assemblies in water.

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2004-05, Vol.2 (9), p.1271-1273
Main Authors: Langereis, Sander, Kooistra, Homme-Auke T, van Genderen, Marcel H P, Meijer, E W
Format: Article
Language:English
Subjects:
Avidin - chemistry
Biotin - chemistry
Contrast Media - chemistry
Gadolinium DTPA - chemical synthesis
Gadolinium DTPA - chemistry
Magnetic Resonance Imaging
Molecular Structure
Protein Structure, Secondary
Water - chemistry
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Description
Summary:A biotinylated Gd-DTPA complex is designed to study the biotin-avidin complexation using the longitudinal relaxivity of this new MRI label, which illustrates the use of MRI contrast agents to probe the formation of supramolecular assemblies in water.
ISSN:1477-0520
1477-0539
DOI:10.1039/b402917h