Prognostic value of two-dimensional echocardiography and N-terminal proatrial natriuretic peptide following an acute myocardial infarction. Assessment of baseline values (2–7 days) and changes at 3 months in patients with a preserved systolic function

Aims The purpose of this prospective, observational study was to evaluate the relationship of left ventricular volumes, systolic function and plasma N-terminal proatrial natriuretic peptide (Nt-proANP) to cardiac morbidity and mortality in post-myocardial infarction patients with left ventricular ej...

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Bibliographic Details
Published in:European heart journal 2002-07, Vol.23 (13), p.1011-1020
Main Authors: Otterstad, J.E., St. John Sutton, M.G., Froeland, G.S., Holme, I., Skjærpe, T., Hall, C.
Format: Article
Language:English
Subjects:
Aged
Atrial Natriuretic Factor - blood
Biological and medical sciences
Biomarkers - blood
Cardiology. Vascular system
Coronary heart disease
Female
Heart
Humans
left ventricular remodelling
Male
Medical sciences
Middle Aged
Myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - diagnostic imaging
Myocardial Infarction - mortality
N-terminal proatrial natriuretic factor
Norway
Prognosis
Proportional Hazards Models
Prospective Studies
Protein Precursors - blood
Stroke Volume
two-dimensional echocardiography
Ultrasonography
Ventricular Dysfunction, Left - blood
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Remodeling
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Summary:Aims The purpose of this prospective, observational study was to evaluate the relationship of left ventricular volumes, systolic function and plasma N-terminal proatrial natriuretic peptide (Nt-proANP) to cardiac morbidity and mortality in post-myocardial infarction patients with left ventricular ejection fraction ≥40%. Methods and Results Two-dimensional echocardiographic recordings and Nt-proANP measurements were obtained in 834 patients who survived acute myocardial infarction. Patients were examined at 2–7 days and 3 months after the index infarction and followed up for 24 months. All measurements of left ventricular volumes, ejection fraction and Nt-proANP were performed in core laboratories. During follow-up 102 patients sustained one or more incidents of the combined primary end-point: cardiac death (n=11), recurrent infarction (n=55) or heart failure requiring hospitalization or treatment with an ACE inhibitor and a diuretic (n=52). Using Cox proportional hazards model, baseline Nt-proANP predicted these events (chi-square 25·3, P
ISSN:0195-668X
1522-9645
DOI:10.1053/euhj.2001.2969