Circulating IL-6 and sIL-6R in Patients with Hepatocellular Carcinoma

: Interleukin‐6 plays a central role in regulating the immune system, hematopoiesis, and acute phase reaction. It interacts with a receptor complex consisting of a specific ligand‐binding protein (IL‐6R, gp80) and a signal transduction protein (gp130). In this report, serum levels of IL‐6 and a solu...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2002-06, Vol.963 (1), p.46-52
Main Authors: GIANNITRAPANI, L., CERVELLO, M., SORESI, M., NOTARBARTOLO, M., LA ROSA, M., VIRRUSO, L., D'ALESSANDRO, N., MONTALTO, G.
Format: Article
Language:English
Subjects:
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - immunology
Female
gp130
hepatocellular carcinoma
Humans
interleukin-6
Interleukin-6 - blood
Interleukin-6 - immunology
liver function tests
Liver Neoplasms - blood
Liver Neoplasms - immunology
Male
Middle Aged
receptor
Receptors, Interleukin-6 - blood
Receptors, Interleukin-6 - immunology
signal transduction protein
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Summary:: Interleukin‐6 plays a central role in regulating the immune system, hematopoiesis, and acute phase reaction. It interacts with a receptor complex consisting of a specific ligand‐binding protein (IL‐6R, gp80) and a signal transduction protein (gp130). In this report, serum levels of IL‐6 and a soluble form of the interleukin‐6 receptor (sIL‐6R) were evaluated in patients with hepatocellular carcinoma. The correlation between IL‐6 and sIL‐6R values, the stage of hepatocellular carcinoma, and main liver function tests was also studied.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2002.tb04093.x