The half-life of the transcript encoding the folate receptor alpha in KB cells is reduced by cytosolic proteins expressed in folate-replete and not in folate-depleted cells

The KB cell, a transformed human cell line, constitutively expresses a high level of the glycosylphosphatidylinositol (GPI) anchored folate receptor protein alpha (FR alpha) and thereby can grow in medium containing

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Bibliographic Details
Published in:Gene 2002-05, Vol.291 (1-2), p.149-158
Main Authors: Sadasivan, Easwara, Regec, Annette, Rothenberg, Sheldon P
Format: Article
Language:English
Subjects:
Blotting, Northern
Carrier Proteins - genetics
Carrier Proteins - metabolism
Cytosol - metabolism
Dose-Response Relationship, Drug
Electrophoretic Mobility Shift Assay
Folate Receptors, GPI-Anchored
Folic Acid - pharmacology
Gene Expression Regulation - drug effects
Half-Life
Humans
Receptors, Cell Surface
RNA Stability - drug effects
RNA, Messenger - genetics
RNA, Messenger - metabolism
Transcription, Genetic
Tumor Cells, Cultured
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Description
Summary:The KB cell, a transformed human cell line, constitutively expresses a high level of the glycosylphosphatidylinositol (GPI) anchored folate receptor protein alpha (FR alpha) and thereby can grow in medium containing
ISSN:0378-1119
DOI:10.1016/S0378-1119(02)00591-7