A Multiantioxidant Supplementation Reduces Damage from Ischaemia Reperfusion in Patients after Lower Torso Ischaemia. A Randomised Trial

Background: open repair of intra-abdominal aortic aneurysm (AAA) is associated with lower torso ischaemia and reperfusion Objective: to examine the effect of antioxidants on the activation and sequestration of white blood cells and muscle injury during AAA repair. Method: forty-two patients undergoi...

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Bibliographic Details
Published in:European journal of vascular and endovascular surgery 2002-06, Vol.23 (6), p.486-490
Main Authors: Wijnen, M.H.W.A., Roumen, R.M.H., Vader, H.L., Goris, R.J.A.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aneurysm
Antioxidants
Antioxidants - therapeutic use
Aortic Aneurysm, Abdominal - surgery
Blood Vessel Prosthesis Implantation - adverse effects
Drug Therapy, Combination
Female
Free Radical Scavengers - therapeutic use
Humans
Ischaemia
Leucocytes
Leukocytes - physiology
Lipofuscin - blood
Lipofuscine
Male
Middle Aged
Oxidative Stress - physiology
Reperfusion
Reperfusion Injury - diagnosis
Reperfusion Injury - drug therapy
Reperfusion Injury - etiology
Transferases - blood
Vitamins - therapeutic use
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Summary:Background: open repair of intra-abdominal aortic aneurysm (AAA) is associated with lower torso ischaemia and reperfusion Objective: to examine the effect of antioxidants on the activation and sequestration of white blood cells and muscle injury during AAA repair. Method: forty-two patients undergoing elective infrarenal aneurysm repair, were randomised to either standard therapy (22 patients) or standard therapy with additional multiantioxidant supplementation (20 patients). Vitamin E and C, Allopurinol, N-acetylcysteine and mannitol was administered perioperatively. White blood cell count (WBC), serum creatine kinase, aspartateaminotransferase, lactate and lipofuscine were measured. Results: WBC remained higher after reperfusion in the antioxidant group (p = 0.008). CK, ASAT and lipofuscine levels were significantly lower after reperfusion in the antioxidant group (p = 0.02,p = 0.018, p = 0.017). Conclusion: multi-antioxidant supplementation was associated with a reduction in serum CK and ASAT after AAA repair. This is likely due to a reduction in oxidative stress and a decreased leucocyte sequestration and activation.
ISSN:1078-5884
1532-2165
DOI:10.1053/ejvs.2002.1614