Synthesis and Applications of End-Labeled Neoglycopolymers

Neoglycopolymers that vary in length and contain a single fluorescent reporter group were synthesized using ring-opening metathesis polymerization (ROMP). The utility of these materials is demonstrated by the development of a cellular binding assay for L-selectin, a cell surface protein that plays a...

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Bibliographic Details
Published in:Organic letters 2002-07, Vol.4 (14), p.2293-2296
Main Authors: Owen, Robert M, Gestwicki, Jason E, Young, Travis, Kiessling, Laura L
Format: Article
Language:English
Subjects:
Binding Sites
Cyclopentanes - chemical synthesis
E-Selectin - chemistry
Fluorescent Dyes - chemistry
Galactose - analogs & derivatives
Galactose - chemical synthesis
Humans
Indicators and Reagents
Jurkat Cells
Leukocytes - chemistry
Ligands
Magnetic Resonance Spectroscopy
Membrane Glycoproteins - chemistry
Polymers - chemical synthesis
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Description
Summary:Neoglycopolymers that vary in length and contain a single fluorescent reporter group were synthesized using ring-opening metathesis polymerization (ROMP). The utility of these materials is demonstrated by the development of a cellular binding assay for L-selectin, a cell surface protein that plays a role in inflammation. The data reveal that these multivalent ligands interact with multiple copies of L-selectin.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0259239