Expression of HIP/PAP mRNA in Human Hepatoma Cell Lines

: The present study attempts to shed more light on the role of hepatocarcinoma‐intestine‐pancreas/pancreatic associated protein (HIP/PAP) in hepatoma cells. We initially examined, by reverse transcription‐polymerase chain reaction (RT‐PCR), the HIP/PAP transcripts present in human hepatoma cell line...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2002-06, Vol.963 (1), p.53-58
Main Authors: CERVELLO, M., GIANNITRAPANI, L., LA ROSA, M., NOTARBARTOLO, M., D'ALESSANDRO, N., VIRRUSO, L., IOVANNA, J. L., MONTALTO, G.
Format: Article
Language:English
Subjects:
Acute-Phase Proteins - biosynthesis
Acute-Phase Proteins - genetics
Antigens, Neoplasm
Biomarkers, Tumor
carcinoma
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
hepatoma
HIP/PAP
Humans
Lectins, C-Type
Liver Neoplasms - metabolism
N-Glycosyl Hydrolases
pancreatitis
Pancreatitis - complications
Pancreatitis-Associated Proteins
Plant Proteins - biosynthesis
Plant Proteins - genetics
protein
Ribosome Inactivating Proteins, Type 1
RNA, Messenger - biosynthesis
Tumor Cells, Cultured
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Summary:: The present study attempts to shed more light on the role of hepatocarcinoma‐intestine‐pancreas/pancreatic associated protein (HIP/PAP) in hepatoma cells. We initially examined, by reverse transcription‐polymerase chain reaction (RT‐PCR), the HIP/PAP transcripts present in human hepatoma cell lines of different origins and with different grades of differentiation and genetic profiles. We also used DNA sequencing analysis to investigate the structure of the HIP/PAP gene. Further investigation is necessary to define the role of HIP/PAP during the development of human hepatocellular carcinoma and to ascertain whether the use of different transcripts is helpful in regulating HIP/PAP expression in transformed liver cells.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2002.tb04094.x