Drug release from carbomer:carbomer sodium salt matrices with potential use as mucoadhesive drug delivery system

In vitro mucoadhesion, water uptake, and drug release of nystatin (N) from matrices of carbomer (C) and lyophilized carbomer sodium salt (CNa L) mixtures were evaluated. Matrices with different ratios C:CNa L were prepared by direct compression. Commercial C as well as lyophilized powder (C L) were...

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Bibliographic Details
Published in:International journal of pharmaceutics 2004-05, Vol.276 (1), p.59-66
Main Authors: Llabot, Juan M, Manzo, Ruben H, Allemandi, Daniel A
Format: Article
Language:English
Subjects:
Acrylic Resins - chemistry
Antifungal Agents - administration & dosage
Antifungal Agents - chemistry
Antifungal Agents - pharmacokinetics
Biological and medical sciences
Carbomer
Drug Delivery Systems
Drug release
General pharmacology
Medical sciences
Mucoadhesive tablets
Nystatin
Nystatin - administration & dosage
Nystatin - chemistry
Nystatin - pharmacokinetics
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Super Case II transport
Tablets
Water - chemistry
Water uptake
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Summary:In vitro mucoadhesion, water uptake, and drug release of nystatin (N) from matrices of carbomer (C) and lyophilized carbomer sodium salt (CNa L) mixtures were evaluated. Matrices with different ratios C:CNa L were prepared by direct compression. Commercial C as well as lyophilized powder (C L) were used. In vitro mucoadhesion increased as the proportion of C in the matrix was raised. The same effect was observed when C was replaced by C L. Matrices in which C was replaced by C L showed an increase of both water uptake and release rates. Besides, the release of N from matrices C L:CNa L exhibited a kinetics with Super Case II ( n>1) mechanism. However, for C:CNa L matrices, drug release was slower and exhibited a biphasic profile with a first stage characterized by either an anomalous ( n
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2004.02.006